Abstract

Quercetin on wounds could be favorable for healing based on its variety of biological effects. Eighty wounded rats were divided into four groups i.e. dimethyl sulfoxide, 0.03% quercetin, 0.1% quercetin, and 0.3% quercetin-treated. Different treatments were topically applied for 20 days. Quercetin (0.3%) caused the fastest wound closure and markedly improved the oxidative stress. Quercetin treatment increased the expressions of IL-10, VEGF, TGF-β₁, CD31, α-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-α. Early infiltration of inflammatory cells and formation of good quality granulation tissue dominated by fibroblast proliferation, angiogenesis, and collagen deposition in quercetin treated groups was also evident. All these effects were more pronounced at 0.3% quercetin concentration. The earliest regeneration of epithelial layer was also observed in 0.3% quercetin-treated wounds. In conclusion, 0.3% quercetin accelerates wound healing efficiently by modulating antioxidant system of wound, cytokines, growth factors, other proteins and cells involved in healing.

摘要

基于其多种生物效应，伤口上的槲皮素可能有利于愈合。80只受伤大鼠被分成四组，即二甲亚砜、0.03%槲皮素、0.1%槲皮素和0.3%槲皮素处理。不同的治疗被局部应用20天。槲皮素 (0.3%) 导致伤口闭合最快，并显着改善氧化应激。槲皮素处理增加IL-10，VEGF，TGF-β的表达₁、CD31、α-SMA、PCNA 和 GAP-43，并降低 TNF-α 的表达。在槲皮素治疗组中，炎症细胞的早期浸润和以成纤维细胞增殖、血管生成和胶原沉积为主的优质肉芽组织的形成也很明显。所有这些效果在 0.3% 槲皮素浓度下更为明显。在 0.3% 槲皮素处理的伤口中也观察到最早的上皮层再生。总之，0.3% 槲皮素通过调节伤口的抗氧化系统、细胞因子、生长因子、其他参与愈合的蛋白质和细胞，有效地加速伤口愈合。