ABSTRACT Small-sized gold nanoparticles (∼3nm) coated with Glutathione (GSH) ligand have designed as an active agent in photothermal therapy (PTT). GSH is pH-sensitive surface that have a fast response property to the variation in pH conditions, especially between normal (∼7.4) and cancer cell (6–6.5), that help the evaluation of the target and toxic effect of the cancer rather than normal cells. Results revealed considerable toxic effects of GSH-AuNPs accumulation in cancer cells for both green and NIR laser irradiation. The GSH-AuNPs represent promising agents for developing the safety issues of photothermal cancer treatment by; the selective targeting of the cancer rather than normal cells, reducing the NPs toxicity by their size overlapping with the renal clearance barrier of kidney filtration (~5.5 nm), and promoting the photothermal performance in the NIR region, in which light penetration into deep cancer regions are more interested.

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谷胱甘肽（GSH）修饰的小尺寸金纳米粒子增强癌细胞的光热疗法

摘要 涂有谷胱甘肽 (GSH) 配体的小尺寸金纳米粒子 (~3nm) 已被设计为光热疗法 (PTT) 中的活性剂。GSH 是 pH 敏感表面，对 pH 条件的变化具有快速响应特性，特别是在正常细胞 (~7.4) 和癌细胞 (6-6.5) 之间，有助于评估癌症的靶点和毒性作用，而不是正常细胞。结果显示，对于绿色和近红外激光照射，GSH-AuNPs 在癌细胞中的积累具有相当大的毒性作用。GSH-AuNPs 代表了通过以下方式解决光热癌症治疗安全问题的有希望的试剂；选择性靶向癌症而不是正常细胞，通过与肾脏过滤的肾脏清除屏障（~5.5 nm）重叠的大小来降低 NPs 的毒性，