Abstract

Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3 − 17) were isolated from the stems of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cycloaddition reaction was also proposed. Some isolated compounds were evaluated for their cytotoxic activities. Compounds 1, 14, and 15 showed moderate cytotoxic effects against T-cell acute lymphoblastic cells (MOLT-3), with IC₅₀ values of 7.83 ± 0.83, 6.53 ± 1.01, and 4.20 ± 0.29 μM, respectively. Additionally, compound 15 exhibited moderate cytotoxicity against cervical carcinoma cells (HeLa) with an IC₅₀ value of 7.00 ± 3.15 μM.

摘要

从Uvaria micrantha（番荔枝科）的茎中分离出两种新型苯醌，uvarmicranones A ( 1 ) 和 B ( 2 )，以及 15 种已知化合物 ( 3  -  17 )。它们的结构通过核磁共振和高分辨率质量数据的分析得到阐明。还提出了通过Diels-Alder 环加成反应合成 uvarmicranone A ( 1 )的合理生物合成途径。评估了一些分离的化合物的细胞毒活性。化合物1，14，和15个显示中等细胞毒性作用Ť -cell急性淋巴母细胞细胞（MOLT-3）中，用IC ₅₀值分别为 7.83 ± 0.83、6.53 ± 1.01 和 4.20 ± 0.29 μM。此外，化合物15对宫颈癌细胞 (HeLa) 表现出中等的细胞毒性，IC ₅₀值为 7.00 ± 3.15 μM。