Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment. It encodes 28 multifunctional proteins that induce an imbalance in the metabolic and proteostatic homeostasis in infected cells. Recently, proteomic approaches have allowed the evaluation of the impact of SARS-CoV-2 infection in human cells. Here, we discuss the current use of proteomics in three major application areas: (i) virus-protein interactomics, (ii) differential proteotyping to map the virus-induced changes in different cell types, and (iii) diagnostic methods for coronavirus infectious disease 2019 (COVID-19). Since the nasal cavity is one of the entry sites for SARS-CoV-2, we will also discuss the potential application of olfactory proteomics to provide novel insights into the olfactory dysfunction triggered by SARS-CoV-2 in patients with COVID-19.

与其他 RNA 病毒一样，严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 在宿主细胞中复制，不断调节分子环境。它编码 ​​28 种多功能蛋白质，可诱导受感染细胞代谢和蛋白质稳态失衡。最近，蛋白质组学方法可以评估 SARS-CoV-2 感染对人类细胞的影响。在这里，我们讨论蛋白质组学目前在三个主要应用领域的应用：（i）病毒-蛋白质相互作用组学，（ii）差异蛋白质分型以绘制不同细胞类型中病毒诱导的变化，以及（iii）冠状病毒传染病的诊断方法2019 年（新冠肺炎 (COVID-19)）。由于鼻腔是 SARS-CoV-2 的进入部位之一，我们还将讨论嗅觉蛋白质组学的潜在应用，为 SARS-CoV-2 引发的 COVID-19 患者嗅觉功能障碍提供新的见解。