Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron‐sized NiO because they may dissolve slowly and produce many more Ni ions. We confirmed the hypothesis that the slow dissolution of NiONPs induces a change in inflammatory response over time.

中文翻译：

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气管内滴注氧化镍纳米颗粒后大鼠肺部炎症反应随时间的变化

氧化镍纳米颗粒（NiONP）是代表性的金属氧化物纳米颗粒，被归类为不溶性镍化合物。我们之前的研究表明，NiONPs 比微米尺寸的 NiO 具有更大的肺毒性，因为它们可能溶解缓慢并产生更多的 Ni 离子。我们证实了这样的假设：NiONP 的缓慢溶解会随着时间的推移引起炎症反应的变化。