Elimination profiles of microdosed ostarine mimicking contaminated products ingestion.,Drug Testing and Analysis

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Elimination profiles of microdosed ostarine mimicking contaminated products ingestion.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-09-22 , DOI: 10.1002/dta.2933
Katja Walpurgis ₁ , Ana Rubio ₁ , Felicitas Wagener ₁ , Oliver Krug ₁ , Andre Knoop ₁ , Christian Görgens ₁ , Sven Guddat ₁ , Mario Thevis _{1,

2}

Affiliation

The possibility of nutritional supplement contamination with minute amounts of the selective androgen receptor modulator (SARM) ostarine has become a major concern for athletes and result managing authorities. In case of an adverse analytical finding (AAF), affected athletes need to provide conclusive information, demonstrating that the test result originates from a contamination scenario rather than doping. The aim of this research project was to study the elimination profiles of microdosed ostarine and characterize the time‐dependent urinary excretion of the drug and selected metabolites. Single‐ and multi‐dose administration studies with 1, 10, and 50 μg of ostarine were conducted, and collected urine samples were analyzed by LC‐MS/MS following solid‐phase extraction or enzymatic hydrolysis combined with liquid‐liquid extraction.

中文翻译：

模拟受污染产品摄入的微剂量 ostarine 的消除曲线。

微量选择性雄激素受体调节剂 (SARM) ostarine 导致营养补充剂污染的可能性已成为运动员和结果管理机构的主要关注点。如果出现不良分析结果 (AAF)，受影响的运动员需要提供结论性信息，证明测试结果源自污染场景而非兴奋剂。该研究项目的目的是研究微剂量 ostarine 的消除曲线，并表征药物和选定代谢物的时间依赖性尿排泄。使用 1、10 和 50 μg ostarine 进行单剂量和多剂量给药研究，并在固相萃取或酶水解结合液-液萃取后通过 LC-MS/MS 分析收集的尿样。

更新日期：2020-09-22

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