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Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes.
Developmental Dynamics ( IF 2.0 ) Pub Date : 2020-09-22 , DOI: 10.1002/dvdy.254 Joanne Wong 1 , Anastasios Damdimopoulos 2 , Pauliina Damdimopoulou 3 , Jemma G Gasperoni 1 , Stephanie C Tran 1 , Sylvia V H Grommen 1 , Bert De Groef 1 , Sebastian Dworkin 1
Developmental Dynamics ( IF 2.0 ) Pub Date : 2020-09-22 , DOI: 10.1002/dvdy.254 Joanne Wong 1 , Anastasios Damdimopoulos 2 , Pauliina Damdimopoulou 3 , Jemma G Gasperoni 1 , Stephanie C Tran 1 , Sylvia V H Grommen 1 , Bert De Groef 1 , Sebastian Dworkin 1
Affiliation
The transcription factor pleomorphic adenoma gene 1 (PLAG1) is required for male fertility. Mice deficient in PLAG1 exhibit decreased sperm motility and abnormal epididymal tubule elongation and coiling, indicating impaired sperm maturation during epididymal transit. However, the downstream transcriptomic profile of the Plag1 knockout (KO; Plag1−/−) murine epididymis is currently unknown.
中文翻译：
Plag1 缺陷小鼠附睾的转录组分析表明精子成熟和细胞外基质基因失调。
男性生育需要转录因子多形性腺瘤基因 1 (PLAG1)。缺乏 PLAG1 的小鼠表现出精子活力降低和附睾小管伸长和卷曲异常，表明附睾运输过程中精子成熟受损。然而，Plag1敲除（KO；Plag1 -/-）鼠附睾的下游转录组学特征目前未知。
更新日期：2020-09-22
中文翻译：
Plag1 缺陷小鼠附睾的转录组分析表明精子成熟和细胞外基质基因失调。
男性生育需要转录因子多形性腺瘤基因 1 (PLAG1)。缺乏 PLAG1 的小鼠表现出精子活力降低和附睾小管伸长和卷曲异常，表明附睾运输过程中精子成熟受损。然而，Plag1敲除（KO；Plag1 -/-）鼠附睾的下游转录组学特征目前未知。
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