Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro,ChemMedChem

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Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro
ChemMedChem ( IF 3.6 ) Pub Date : 2020-09-22 , DOI: 10.1002/cmdc.202000420
Wei Ren _{1,

2,

3} , Fuchun Nan ₄ , Shumu Li _{2,

3} , Sijin Yang ₁ , Jiechao Ge ₄ , Zhenwen Zhao _{2,

3}

Affiliation

Negatively charged fluorescent carbon dots (CDs, E_m=608 nm) were hydrothermally prepared from thiophene phenylpropionic acid polymers and then successfully loaded with the positively charged anticancer cargo coptisine, which suffers from poor bioavailability. The formed CD‐coptisine complexes were thoroughly characterized by particle size, morphology, drug loading efficiency, drug release, cellular uptake and cellular toxicity in vitro and antitumor activities in vivo. In this nano‐carrier system, red emissive CDs possess multiple advantages as follows: 1) high drug loading efficiency (>96 %); 2) sustained drug release; 3) enhanced drug efficacy towards cancer cells; 4) EPR effect; 5) drug release tracing with near‐infrared imaging. These properties indicated that red emissive CDs prepared from polymers could be used as a novel drug delivery system with integrated therapeutic and imaging functions in cancer therapy, which are expected to have great potential in future clinical applications.

中文翻译：

由聚合物制备的红色发射碳点作为体内和体外黄连素递送的有效纳米载体

带负电的荧光碳点 (CDs, E _m=608 nm) 由噻吩苯丙酸聚合物水热制备，然后成功负载带正电荷的抗癌货物黄连碱，其生物利用度较差。形成的 CD-黄连素复合物通过粒径、形态、载药效率、药物释放、体外细胞摄取和细胞毒性以及体内抗肿瘤活性进行了彻底表征。在该纳米载体系统中，红色发光 CDs 具有以下多个优点：1）载药效率高（>96%）；2) 缓释药物；3) 增强对癌细胞的药效；4）EPR效果；5) 近红外成像的药物释放追踪。

更新日期：2020-09-22

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