NO inhibitory carbazole alkaloids from the folk medicine Murraya tetramera C. C. Huang,Chemistry & Biodiversity

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NO inhibitory carbazole alkaloids from the folk medicine Murraya tetramera C. C. Huang
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-11-01 , DOI: 10.1002/cbdv.202000490
Hai-Ning Lyu _{1,

2} , Ying Zhou _{1,

3} , Ran Wen _{1,

4} , Peng-Fei Tu ₁ , Yong Jiang ₁

Affiliation

The phytochemical investigation of the leaves and stems of Murraya tetramera C.C. Huang, a traditional folk medicine used as an anti‐inflammatory agent, yielded 19 simple carbazole alkaloids, two of which (1‐ethoxy‐3‐methyl‐9H‐carbazol‐2‐ol (1) and 7‐hydroxy‐2,8‐dimethoxy‐6‐methyl‐9H‐carbazole‐1‐carbaldehyde (2)) are new ones. The structures of the new compounds were determined by extensive spectroscopic analysis including NMR and HR‐EI‐MS experiments, as well as comparison with the reported data. Most of the isolates showed potent inhibitory effects on NO production in LPS‐stimulated BV‐2 microglial cells with IC50 values ranging from 5.1 to 15.1 μM.

中文翻译：

来自民间医药四聚体 CC Huang 的 NO 抑制性咔唑生物碱

Murraya tetramera CC Huang 叶和茎的植物化学研究，一种用作抗炎剂的传统民间药物，产生了 19 种简单的咔唑生物碱，其中两种（1-乙氧基-3-甲基-9H-咔唑-2- ol (1) 和 7-羟基-2,8-二甲氧基-6-甲基-9H-咔唑-1-甲醛 (2)) 是新的。新化合物的结构是通过广泛的光谱分析确定的，包括 NMR 和 HR-EI-MS 实验，以及与报告数据的比较。大多数分离株对 LPS 刺激的 BV-2 小胶质细胞中的 NO 产生具有强效抑制作用，IC50 值范围为 5.1 至 15.1 μM。

更新日期：2020-11-01

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