Antivitamins B12 - Some Inaugural Milestones.,Chemistry - A European Journal

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Antivitamins B12 - Some Inaugural Milestones.
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2020-09-21 , DOI: 10.1002/chem.202003788
Bernhard Kräutler ₁

Affiliation

The recently delineated structure‐ and reactivity‐based concept of antivitamins B₁₂ has begun to bear fruit by the generation, and study, of a range of such B₁₂‐dummies, either vitamin B₁₂‐derived, or transition metal analogues that also represent potential antivitamins B₁₂ or specific B₁₂‐antimetabolites. As reviewed here, this has opened up new research avenues in organometallic B₁₂‐chemistry and bioinorganic coordination chemistry. Exploratory studies with antivitamins B₁₂ have, furthermore, revealed some of their potential, as pharmacologically interesting compounds, for inducing B₁₂‐deficiency in a range of organisms, from hospital resistant bacteria to laboratory mice. The derived capacity of antivitamins B₁₂ to induce functional B₁₂‐deficiency in mammalian cells and organs also suggest their valuable potential as growth inhibitors of cancerous human and animal cells.

中文翻译：

抗维生素 B12 - 一些开创性的里程碑。

_{最近描述的基于结构和反应性的抗维生素 B 12}概念已开始通过一系列此类 B ₁₂假体（维生素 B ₁₂衍生的或也代表的过渡金属类似物）的生成和研究而结出硕果。潜在的抗维生素 B ₁₂或特定的 B ₁₂抗代谢物。_{正如本文所述，这为有机金属 B 12}化学和生物无机配位化学开辟了新的研究途径。此外，抗维生素 B ₁₂的探索性研究揭示了它们作为药理学上有趣的化合物的一些潜力，可在一系列生物体（从医院耐药细菌到实验室小鼠）中诱导 B _12缺乏。_{抗维生素 B 12}诱导哺乳动物细胞和器官功能性 B ₁₂缺乏的能力也表明它们作为人类和动物癌细胞生长抑制剂的宝贵潜力。

更新日期：2020-09-21

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