Covalent Linkage and Macrocylization Preserve and Enhance Synergistic Interactions in Catalytic Amyloids,ChemBioChem

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Covalent Linkage and Macrocylization Preserve and Enhance Synergistic Interactions in Catalytic Amyloids
ChemBioChem ( IF 2.6 ) Pub Date : 2020-09-21 , DOI: 10.1002/cbic.202000645
Zsofia Lengyel-Zhand ₁ , Liam R Marshall ₁ , Maximilian Jung ₂ , Megha Jayachandran ₁ , Min-Chul Kim ₁ , Austin Kriews ₁ , Olga V Makhlynets ₁ , H Christopher Fry ₃ , Armin Geyer ₂ , Ivan V Korendovych ₁

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How might complexity arise from short peptides? Synergistic interactions between the side chains of catalytic amyloids are locked into place by linkers between the peptides, and these new designs result in faster assembly and asymmetric assemblies. These could serve as a potential link in the evolutionary path between abiotic peptides and complex enzymes.