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Development of a Novel Intravascular Oxygenator Catheter: Oxygen Mass Transfer Properties Across Non-Porous Hollow Fiber Membranes.
Biotechnology and Bioengineering ( IF 3.5 ) Pub Date : 2020-09-22 , DOI: 10.1002/bit.27574 Stewart Farling 1 , Tobias L Straube 2 , Travis P Vesel 2 , Nick Bottenus 3, 4 , Bruce Klitzman 3, 5 , Ira M Cheifetz 2, 6 , Marc A Deshusses 1, 7
Biotechnology and Bioengineering ( IF 3.5 ) Pub Date : 2020-09-22 , DOI: 10.1002/bit.27574 Stewart Farling 1 , Tobias L Straube 2 , Travis P Vesel 2 , Nick Bottenus 3, 4 , Bruce Klitzman 3, 5 , Ira M Cheifetz 2, 6 , Marc A Deshusses 1, 7
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Despite hypoxic respiratory failure representing a large portion of total hospitalizations and healthcare spending worldwide, therapeutic options beyond mechanical ventilation are limited. We demonstrate the technical feasibility of providing oxygen to a bulk medium, such as blood, via diffusion across nonporous hollow fiber membranes (HFMs) using hyperbaric oxygen. The oxygen transfer across Teflon® membranes was characterized at oxygen pressures up to 2 bars in both a stirred tank vessel (CSTR) and a tubular device mimicking intravenous application. Fluxes over 550 ml min−1 m−2 were observed in well‐mixed systems, and just over 350 ml min−1 m−2 in flow through tubular systems. Oxygen flux was proportional to the oxygen partial pressure inside the HFM over the tested range and increased with mixing of the bulk liquid. Some bubbles were observed at the higher pressures (1.9 bar) and when bulk liquid dissolved oxygen concentrations were high. High‐frequency ultrasound was applied to detect and count individual bubbles, but no increase from background levels was detected during lower pressure operation. A conceptual model of the oxygen transport was developed and validated. Model parametric sensitivity studies demonstrated that diffusion through the thin fiber walls was a significant resistance to mass transfer, and that promoting convection around the fibers should enable physiologically relevant oxygen supply. This study indicates that a device is within reach that is capable of delivering greater than 10% of a patient's basal oxygen needs in a configuration that readily fits intravascularly.
中文翻译：
新型血管内氧合器导管的开发：无孔中空纤维膜的氧传质特性。
尽管缺氧性呼吸衰竭占全球住院总费用和医疗保健支出的很大一部分，但机械通气以外的治疗选择是有限的。我们证明了通过使用高压氧穿过无孔中空纤维膜 (HFM) 向大量介质（例如血液）提供氧气的技术可行性。在搅拌罐容器 (CSTR) 和模拟静脉内应用的管状装置中，通过 Teflon® 膜的氧气转移的特点是氧气压力高达 2 巴。在充分混合的系统中观察到超过 550 ml min -1 m -2 的通量，并且仅超过 350 ml min -1 m -2在流经管状系统中。在测试范围内，氧通量与 HFM 内的氧分压成正比，并随着大量液体的混合而增加。在较高压力 (1.9 bar) 和大量液体溶解氧浓度高时观察到一些气泡。应用高频超声检测和计数单个气泡，但在低压操作期间未检测到背景水平的增加。开发并验证了氧气运输的概念模型。模型参数敏感性研究表明，通过薄纤维壁的扩散是对传质的显着阻力，促进纤维周围的对流应该能够提供生理相关的氧气供应。
更新日期：2020-09-22
中文翻译：
新型血管内氧合器导管的开发：无孔中空纤维膜的氧传质特性。
尽管缺氧性呼吸衰竭占全球住院总费用和医疗保健支出的很大一部分，但机械通气以外的治疗选择是有限的。我们证明了通过使用高压氧穿过无孔中空纤维膜 (HFM) 向大量介质（例如血液）提供氧气的技术可行性。在搅拌罐容器 (CSTR) 和模拟静脉内应用的管状装置中，通过 Teflon® 膜的氧气转移的特点是氧气压力高达 2 巴。在充分混合的系统中观察到超过 550 ml min -1 m -2 的通量，并且仅超过 350 ml min -1 m -2在流经管状系统中。在测试范围内，氧通量与 HFM 内的氧分压成正比，并随着大量液体的混合而增加。在较高压力 (1.9 bar) 和大量液体溶解氧浓度高时观察到一些气泡。应用高频超声检测和计数单个气泡，但在低压操作期间未检测到背景水平的增加。开发并验证了氧气运输的概念模型。模型参数敏感性研究表明，通过薄纤维壁的扩散是对传质的显着阻力，促进纤维周围的对流应该能够提供生理相关的氧气供应。
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