Sarcoidosis is an inflammatory systemic disease that commonly affects the lungs or lymph nodes but can manifest in other organs. Herein, we review the latest evidence establishing how innate and adaptive immune responses contribute to the pathogenesis and clinical course of sarcoidosis. We discuss the possible role of microbial organisms as etiologic agents in sarcoidosis and the evidence supporting sarcoidosis as an autoimmune disease. We also discuss how animal and in vitro human models have advanced our understanding of the immunopathogenesis of sarcoidosis. Finally, we discuss therapeutics for sarcoidosis and the effects on the immune system.

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结节病免疫机制的最新观点

结节病是一种炎症性全身疾病，通常会影响肺部或淋巴结，但可在其他器官中表现出来。在本文中，我们回顾了建立先天性和适应性免疫应答如何促进结节病的发病机理和临床过程的最新证据。我们讨论了微生物在结节病中作为病因的可能作用，以及支持结节病为自身免疫性疾病的证据。我们还将讨论动物模型和体外人类模型如何使我们进一步了解结节病的免疫发病机理。最后，我们讨论结节病的治疗方法以及对免疫系统的影响。