Abstract The precise regulation of cell fate by biomaterials is one of the core focuses in tissue engineering and regenerative therapeutics. Cell fate is controlled by the niche signaling cues, including growth factors/morphogens, direct cell-cell contact, and extracellular matrix components. Here, we discuss how to bio-mimic cell-cell interaction by tailoring the interface of biomaterials to design effective scaffolds. Cadherins, as a key cell membrane protein family mediating the intercellular adherens junction, have attracted extensive attention in the functional modification of biomaterials. Therefore, cadherin-based biomaterials, their ability to modulate stem cell fate, and their applications in regenerative medicine are reviewed. Furthermore, we provide an outlook for exploiting the bio-mimic biomaterials in advanced cell therapeutics.

中文翻译：

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基于钙粘蛋白的生物材料：诱导干细胞走向组织构建和治疗

摘要 生物材料对细胞命运的精确调控是组织工程和再生疗法的核心焦点之一。细胞命运由生态位信号线索控制，包括生长因子/形态发生素、直接细胞-细胞接触和细胞外基质成分。在这里，我们讨论如何通过定制生物材料的界面来设计有效的支架来生物模拟细胞间相互作用。钙粘蛋白作为介导细胞间粘附连接的关键细胞膜蛋白家族，在生物材料的功能修饰中引起了广泛关注。因此，综述了基于钙粘蛋白的生物材料、它们调节干细胞命运的能力以及它们在再生医学中的应用。此外，我们提供了在先进细胞疗法中利用仿生生物材料的前景。