Tough and antifouling polyampholyte hydrogels can be prepared through the photopolymerization of the equivalent [2-(acryloyloxy)ethyl]trimethylammonium chloride([TMA][Cl]) and 2-acrylamido-2-methyl-1-propanesulfonic acid sodium([Na][AMPS]) with poly(ethylene glycol) diacrylate (PEGDA). Fourier-transform infrared spectra evidenced the linkage between PEGDA and TMA/AMPS. With the different ratios of TMA to AMPS, the copolymers presented the different morphological surfaces and also exhibited different swelling ratios. Among all copolymers, the equivalent ionic hydrogel A50S50 ([TMA] = [AMPS]) demonstrated the highest mechanical properties with toughness of 230.98 kJm^-1 and compressive strain of 100%. Hydrogel A50S50 also presented the optimal protein fouling ability for both Bovine-serum-albumin (BSA, anionic protein) and Lysozyme (LYZ, cationic protein). On the other hand, A50S50 also showed the biocompatibility (low cytotoxicity and hemolytic ratio), being certified by MTT assay and hemolysis test. A polyampholyte A50S50 with equivalent ionic monomers possessed both tough and antifouling properties, being highly promising for load-bearing and antifouling biomedical applications.

可以通过对等价的[2-（丙烯酰氧基）乙基]三甲基氯化铵（[TMA] [Cl]）和2-丙烯酰胺基-2-甲基-1-丙烷磺酸钠（[Na] [AMPS]）与聚（乙二醇）二丙烯酸酯（PEGDA）。傅立叶变换红外光谱证明了PEGDA和TMA / AMPS之间的联系。在TMA与AMPS的比例不同的情况下，共聚物呈现出不同的形态表面，并且还呈现出不同的溶胀率。在所有共聚物中，等效的离子水凝胶A50S50（[TMA] = [AMPS]）表现出最高的机械性能，韧性为230.98 kJm ^-1压缩应变为100％。水凝胶A50S50还为牛血清白蛋白（BSA，阴离子蛋白）和溶菌酶（LYZ，阳离子蛋白）提供了最佳的蛋白质结垢能力。另一方面，A50S50也显示出生物相容性（低细胞毒性和溶血比），并通过MTT分析和溶血试验证明。具有等效离子单体的聚两性电解质A50S50具有强韧和防污性能，在承重和防污生物医学应用中非常有前途。