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Intracranial Arterial Calcification: Prevalence, Risk Factors, and Consequences
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jacc.2020.07.056
Jonas W Bartstra 1 , Tim C van den Beukel 1 , Wim Van Hecke 2 , Willem P T M Mali 1 , Wilko Spiering 3 , Huiberdina L Koek 4 , Jeroen Hendrikse 1 , Pim A de Jong 1 , Annemarie M den Harder 1
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Intracranial large and small arterial calcifications are a common incidental finding on computed tomography imaging in the general population. Here we provide an overview of the published reports on prevalence of intracranial arterial calcifications on computed tomography imaging and histopathology in relation to risk factors and clinical outcomes. We performed a systematic search in Medline, with a search filter using synonyms for computed tomography scanning, (histo)pathology, different intracranial arterial beds, and calcification. We found that intracranial calcifications are a frequent finding in all arterial beds with the highest prevalence in the intracranial internal carotid artery. In general, prevalence increases with age. Longitudinal studies on calcification progression and intervention studies are warranted to investigate the possible causal role of calcification on clinical outcomes. This might open up new therapeutic directions in stroke and dementia prevention and the maintenance of the healthy brain.

中文翻译:

颅内动脉钙化:患病率、危险因素和后果

颅内大动脉和小动脉钙化是普通人群计算机断层扫描成像中常见的偶然发现。在这里,我们概述了已发表的关于计算机断层扫描成像和组织病理学中颅内动脉钙化患病率与危险因素和临床结果相关的报告。我们在 Medline 中进行了系统搜索,搜索过滤器使用计算机断层扫描、(组织)病理学、不同颅内动脉床和钙化的同义词。我们发现颅内钙化在所有动脉床中都很常见,其中颅内颈内动脉的患病率最高。一般来说,患病率随着年龄的增长而增加。有必要对钙化进展和干预研究进行纵向研究,以调查钙化对临床结果的可能因果作用。这可能会为中风和痴呆症的预防以及大脑健康的维护开辟新的治疗方向。
更新日期:2020-09-01
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