Passive devices that exhibit release of the drug on demand and have the potential to be switched off and on optimally and effectively are advantageous for the treatment of various diseases including diabetes, chronic pain, and cancer. To this end, drug loaded magnetic and non-magnetic microspheres were prepared herein from the natural, biodegradable and environmentally benign polymer, cellulose. These cellulose microspheres were prepared by dissolving the microcrystalline cellulose (MCC) in 1-butyl-3-methylimidazoliumchloride (BmimCl) and dropping the cellulose solution in water to get the bare cellulose beads (BCBs), whereas the magnetic cellulose beads (MCBs) were prepared in situ through diffusing the BCBs in the solution of magnetite nanoparticles (MNP). A model drug, dopamine (DOPA) was loaded through incubating these beads in optimized drug solution. The encapsulation efficiency of these beads was checked at pH 7.4, and release kinetics was investigated. Drug release from the microspheres was enhanced ~46% under the influence of external magnetic field (EMF). Overall, cellulose beads could be suggested as the naturally occurring and biocompatible drug delivery vehicles for the long-term, on-demand new-age drug delivery vehicles that give high reproducibility of cycle-to cycle and device-to-device drug release.

表现出按需释放药物并且有可能被最佳有效地关闭和开启的无源装置对于治疗包括糖尿病，慢性疼痛和癌症在内的各种疾病是有利的。为此，本文由天然的，可生物降解的和对环境有益的聚合物纤维素制备了载有药物的磁性和非磁性微球。这些纤维素微球是通过将微晶纤维素（MCC）溶解在1-丁基-3-甲基咪唑鎓氯化物（BmimCl）中并将纤维素溶液滴入水中制成裸露的纤维素珠（BCB）而制成的磁性纤维素珠（MCB）通过将BCB扩散到磁铁矿纳米颗粒（MNP）溶液中原位制备。示范药物 通过在优化的药物溶液中孵育这些珠粒来加载多巴胺（DOPA）。在pH 7.4下检查了这些珠的包封效率，并研究了释放动力学。在外部磁场（EMF）的影响下，微球中的药物释放增加了〜46％。总体而言，对于长期，按需的新时代药物输送工具，纤维素珠可被建议作为天然存在且具有生物相容性的药物输送工具，这些药物输送工具具有更高的循环周期和装置间释放的重现性。