This study determines the bioaccessibility of toxic and carcinogenic arsenic (As) in composite food samples and evaluates potential exposure from food intake in Bangladesh children. Total As (tAs), inorganic As (iAs) and bioaccessible As (BAs) in food composite samples consumed by children were compared between an exposed and a control group (based on As in drinking water). Total As concentrations in composite food samples of children exposed to mean As level of 331 µg/l in drinking and cooking water ranged from 586 to 1975 µg/kg, dry weight over 76 to 90 µg/kg in the unexposed group. Average iAs in food composites was 73.9% (range: 49.3 to 90.8%). The fraction of BAs using gastric and gastrointestinal phases was 91±13% and 98±11%, respectively. Daily intake of iAs in exposed group ranged from 0.41 to 6.38 µg per kg body weight (BW), which was much higher than the unexposed group (0.08-0.15 µg per kg BW). High iAs content and BAs in composite food samples indicated elevated risk to exposed children. Further research should include both adult and children using larger sample size to determine overall As exposure from food intake in Bangladesh, attention must be given to lowering of As in food.

本研究确定了复合食品样品中有毒和致癌砷 (As) 的生物可及性，并评估了孟加拉国儿童食物摄入的潜在暴露。对暴露组和对照组（基于饮用水中的 As）比较儿童食用的食品复合样品中的总 As (tAs)、无机 As (iAs) 和生物可及 As (BAs)。暴露于饮用水和烹饪水中平均砷含量为 331 微克/升的儿童的复合食品样品中总砷浓度范围为 586 至 1975 微克/千克，未接触组干重超过 76 至 90 微克/千克。食品复合材料中的平均 iAs 为 73.9%（范围：49.3 至 90.8%）。使用胃和胃肠相的 BA 分数分别为 91±13% 和 98±11%。暴露组中 iAs 的每日摄入量范围为 0.41 至 6.38 µg/kg 体重 (BW)，这远高于未暴露组（0.08-0.15 µg/kg BW）。复合食品样品中的高 iAs 含量和 BA 表明接触儿童的风险增加。进一步的研究应包括成人和儿童，使用更大的样本量来确定孟加拉国食物摄入的总体砷暴露，必须注意降低食物中的砷。