A facile route towards new chitin derivatives with both catalytical and biological activities is proposed in the course of methodology development aimed at the design of polyfunctional materials on the basis of renewable and accessible natural polysaccharides. Ultrasound-promoted and Cu(I)-catalyzed azido-alkyne click cycloaddition of the propargylic ester of nicotinic acid and its N-methylated analogue to the azido chitin derivative allowed us to obtain previously unknown non-toxic water-soluble derivatives of chitin. The obtained polymers and their based nanoparticles demonstrated a high antibacterial activity in vitro, which is comparable or even superior to that of commercial antibiotics ampicillin and gentamicin. New derivatives of chitin were also shown to be highly efficient and reusable (at least for 10 times) green catalysts for the aldol reaction in water. The catalysts can be easily separated from the reaction mixture by their precipitation with ethanol. The results obtained highlight prospects of further studies on chitin's application in the rational design of novel functional materials with valuable properties.

在方法开发的过程中，提出了一种具有催化和生物活性的新型几丁质衍生物的简便途径，该方法旨在基于可再生和可利用的天然多糖设计多功能材料。超声促进和Cu（I）催化的叠氮基烟酸的炔丙基酯的烟酰胺及其N-甲基化类似物与叠氮基几丁质衍生物的铜基加价反应使我们能够获得以前未知的甲壳素的无毒水溶性衍生物。所获得的聚合物及其基纳米颗粒在体外显示出高抗菌活性与商业抗生素氨苄西林和庆大霉素相当甚至更好。几丁质的新衍生物还被证明是高效和可重复使用的（至少10倍）绿色催化剂，用于水中的羟醛反应。通过用乙醇沉淀，可以容易地从反应混合物中分离出催化剂。获得的结果突出显示了进一步研究几丁质在合理设计具有有价值特性的新型功能材料中的应用的前景。