Abstract Studies related to biomaterials that stimulate the repair of living tissue have increased considerably, improving the quality of many people's lives that require surgery due to traumatic accidents, bone diseases, bone defects, and reconstructions. Among these biomaterials, bioceramics and bioactive glasses (BGs) have proved to be suitable for coating materials, cement, scaffolds, and nanoparticles, once they present good biocompatibility and degradability, able to generate osteoconduction on the surrounding tissue. However, the role of biomaterials in hard tissue engineering is not restricted to a structural replacement or for guiding tissue regeneration. Nowadays, it is expected that biomaterials develop a multifunctional role when implanted, orchestrating the process of tissue regeneration and providing to the body the capacity to heal itself. In this way, the incorporation of specific metal ions in bioceramics and BGs structure, including magnesium, silver, strontium, lithium, copper, iron, zinc, cobalt, and manganese are currently receiving enhanced interest as biomaterials for biomedical applications. When an ion is incorporated into the bioceramic structure, a new category of material is created, which has several unique properties that overcome the disadvantages of primitive material and favors its use in different biomedical applications. The doping can enhance handling properties, angiogenic and osteogenic performance, and antimicrobial activity. Therefore, this review aims to summarize the effect of selected metal ion dopants into bioceramics and silicate-based BGs in bone tissue engineering. Furthermore, new applications for doped bioceramics and BGs are highlighted, including cancer treatment and drug delivery.

中文翻译：

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用于骨组织工程的最常被引用的金属离子掺杂生物陶瓷和硅酸盐基生物活性玻璃的最新进展

摘要 与刺激活组织修复的生物材料相关的研究显着增加，改善了许多因创伤事故、骨病、骨缺损和重建而需要手术的人的生活质量。在这些生物材料中，生物陶瓷和生物活性玻璃（BGs）已被证明适用于涂层材料、水泥、支架和纳米颗粒，一旦它们表现出良好的生物相容性和可降解性，就能够在周围组织上产生骨传导。然而，生物材料在硬组织工程中的作用并不限于结构替代或引导组织再生。如今，人们期望生物材料在植入时发挥多功能作用，协调组织再生的过程，并为身体提供自愈能力。通过这种方式，在生物陶瓷和 BGs 结构中加入特定的金属离子，包括镁、银、锶、锂、铜、铁、锌、钴和锰，目前作为生物医学应用的生物材料越来越受到关注。当一种离子结合到生物陶瓷结构中时，就产生了一类新的材料，它具有多种独特的性质，克服了原始材料的缺点，有利于其在不同的生物医学应用中的使用。掺杂可以增强处理特性、血管生成和成骨性能以及抗菌活性。所以，本综述旨在总结所选金属离子掺杂剂在骨组织工程中对生物陶瓷和硅酸盐基 BG 的影响。此外，还强调了掺杂生物陶瓷和 BG 的新应用，包括癌症治疗和药物输送。