The mammalian two-pore channels TPC1 and TPC2 are patho-physiologically relevant endo-lysosomal cation channels regulated by the Ca²⁺ mobilising messenger NAADP and the phosphoinositide PI(3,5)P₂. Recent work by Arlt et al shows that genetic or chemical inhibition of TPC1 in mice promotes anaphylaxis in vivo through a mechanism involving enhanced endoplasmic reticulum Ca²⁺ release and secretion in mast cells.

中文翻译：

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防止对系统造成冲击。两孔通道1负调节过敏反应

哺乳动物的两孔通道TPC1和TPC2是由Ca ²⁺动员信使NAADP和磷酸肌醇PI（3,5）P ₂调节的病理生理相关的溶酶体阳离子通道。Arlt等人最近的工作表明，通过涉及内质网Ca ²⁺释放和肥大细胞分泌增强的机制，小鼠中TPC1的遗传或化学抑制作用可促进体内过敏反应。