Infant acute lymphoblastic leukemia (ALL) comprises 2.5%–5% of pediatric ALL with inferior survival compared to older children. A majority of infants (80%) with ALL harbor KMT2A gene rearrangement, which portends a poor prognosis. Approximately 94 different partner genes have been identified to date. The common rearrangements include t(4;11)(q21;q23)KMT2A-AFF1,t(11;19) (q23;p13.3)KMT2A-MLLT1 and t(9;11)(p22;q23)KMT2A-MLLT3. We report a novel translocation t(5;11)(q35;q23)KMT2A-MAML1 in newly diagnosed infant precursor B-ALL. Long-term follow-up and a larger number of patients are needed to better understand its prognostic significance.

与年龄较大的儿童相比，婴儿急性淋巴细胞白血病（ALL）占儿童ALL的2.5％–5％。患有ALL的大多数婴儿（80％）具有KMT2A基因重排，预后不良。迄今为止，已鉴定出约94种不同的伴侣基因。常见的重排包括t（4; 11）（q21; q23）KMT2A-AFF1，t（11; 19）（q23; p13.3）KMT2A-MLLT1和t（9; 11）（p22; q23）KMT2A-MLLT3。我们报告了新诊断的婴儿前体B-ALL中的新型易位t（5; 11）（q35; q23）KMT2A-MAML1。需要长期随访和大量患者以更好地了解其预后意义。