Selective interfacing to small multifunctional nerves such as the vagus nerve (VN) which is the main multimodal autonomic nerve that provides a major communication pathway from vital peripheral organs to the brain, can have significant potential in treating and diagnosing diseases as well as enhancing our understanding of peripheral nerve circuits. Here we describe the fabrication of a 16-channel intraneural electrode array with ultramicro-dimensioned electrodes to achieve improved functionally selective recording. We demonstrate that the amorphous silicon carbide ultramicroelectrode arrays (a-SiC UMEAs) provide selectivity in the detection of neural activity in the cVN related to changes in systemic oxygenation and blood pressure. We will also demonstrate spatially selective recording of micro-compound action potentials (μCAPs) by electrical stimulation of the subdiaphragmatic branches of the VN. Distinct neural activity was recorded on electrodes separated by less than about 100 μm. This is the first time that this level of spatially selectivity recording has been demonstrated in the cVN with an intraneural multielectrode array.

选择性连接小型多功能神经，例如迷走神经（VN），它是主要的多模式自主神经，提供从重要外周器官到大脑的主要通讯途径，在治疗和诊断疾病以及增强我们的理解方面具有巨大潜力周围神经回路。在这里，我们描述了具有超微型电极的 16 通道神经内电极阵列的制造，以实现改进的功能选择性记录。我们证明，非晶碳化硅超微电极阵列（a-SiC UMEA）可以选择性地检测 cVN 中与全身氧合和血压变化相关的神经活动。我们还将展示通过电刺激 VN 膈下分支来空间选择性记录微复合动作电位 (μCAP)。在间隔小于约 100 μm 的电极上记录了明显的神经活动。这是首次通过神经内多电极阵列在 cVN 中证明这种水平的空间选择性记录。