During self-guided movements, we optimise performance by combining sensory and self-motion cues optimally, based on their reliability. Discrepancies between such cues and problems in combining them are suggested to underlie some pain conditions. Therefore, we examined whether visuomotor integration is altered in twenty-two participants with upper or lower limb complex regional pain syndrome (CRPS) compared to twenty-four controls. Participants located targets that appeared in the unaffected (CRPS) / dominant (controls) or affected (CRPS) / non-dominant (controls) side of space, using the hand of their unaffected/dominant or affected/non-dominant side of the body. For each side of space and each hand, participants located the target using visual information and no movement (vision only condition), an unseen pointing movement (self-motion only condition), or a visually-guided pointing movement (visuomotor condition). In all four space-by-hand conditions, controls reduced their variability in the visuomotor compared to the vision and self-motion only conditions and in line with a model prediction for optimal integration. Participants with CRPS showed similar evidence of cue combination in two of the four conditions. However, they had better-than-optimal integration for the unaffected hand in the affected space. Furthermore, they did not integrate optimally for the hand of the affected side of the body in unaffected space, but instead relied on the visual information. Our results suggest that people with CRPS can optimally integrate visual and self-motion cues under some conditions, despite lower reliability of self-motion cues, and use different strategies to controls.

在自我引导的运动过程中，我们根据其可靠性，通过最佳地结合感官和自我运动线索来优化性能。这些线索和将它们结合起来的问题之间的差异被认为是某些疼痛状况的基础。因此，我们检查了与 24 名对照者相比，22 名患有上肢或下肢复杂区域疼痛综合征 (CRPS) 的参与者的视觉运动整合是否发生了改变。参与者使用他们身体的未受影响/优势或受影响/非优势侧的手定位出现在空间的未受影响（CRPS）/优势（控制）或受影响（CRPS）/非优势（控制）一侧的目标. 对于空间的每一侧和每只手，参与者使用视觉信息和无运动（仅视觉条件）定位目标，不可见的指向运动（仅自运动状态），或视觉引导的指向运动（视觉运动状态）。在所有四种手动空间条件下，与仅视觉和自运动条件相比，控件减少了视觉运动的可变性，并符合最佳整合的模型预测。CRPS 的参与者在四种情况中的两种情况下表现出类似的线索组合证据。但是，对于受影响空间中未受影响的手，它们的整合效果优于最佳。此外，它们并没有在未受影响的空间中针对身体受影响一侧的手进行最佳整合，而是依赖于视觉信息。我们的结果表明，尽管自我运动线索的可靠性较低，但患有 CRPS 的人可以在某些条件下最佳地整合视觉和自我运动线索，