Abstract Nitrogen doped carbon nanodots (NDCNDs) and nanosized cobalt tetra aminophenoxy phthalocyanines (CoTAPhPcNPs) modified glassy carbon electrodes have been successfully used in the simultaneous detection of aspirin (ASA), ibuprofen (IBU) and indomethacin (INDO). Scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV–Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to probe the nature of the synthesized nanomaterials. Sequential deposition of the nanomaterials on the glassy carbon electrode yielded CoTAPhPcNPs-NDCNDs-GCE with remarkable electrocatalytic performance. Electro-oxidation of the drugs at the electrode surface was first order. This work demonstrates the synergic effect of the two nanomaterials towards simultaneous electrocatalytic detection of the drugs. Superior detection limits of ASA, IBU and INDO being 9.66 × 10−9 M, 4.19 × 10−9 M and 7.2 × 10−9 M, respectively, were obtained using differential pulse voltammetry. The developed sensor could detect two of the three (ibuprofen and indomethacin) simultaneously at significantly different potentials and exhibited remarkable reproducibility after a regeneration step.

中文翻译：

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氮掺杂碳纳米点和纳米钴酞菁共轭修饰玻碳电极同时电检测非甾体抗炎药

摘要 掺氮碳纳米点（NDCNDs）和纳米四氨基苯氧基酞菁钴（CoTAPhPcNPs）修饰的玻碳电极已成功用于同时检测阿司匹林（ASA）、布洛芬（IBU）和吲哚美辛（INDO）。扫描电子显微镜 (SEM)、透射电子显微镜 (TEM)、紫外-可见光谱、傅里叶变换红外光谱 (FTIR)、循环伏安法 (CV) 和电化学阻抗谱 (EIS) 用于探测合成纳米材料的性质。纳米材料在玻璃碳电极上的顺序沉积产生了具有显着电催化性能的 CoTAPhPcNPs-NDCNDs-GCE。药物在电极表面的电氧化是一级反应。这项工作证明了两种纳米材料对药物同时电催化检测的协同作用。ASA、IBU 和 INDO 的检测限分别为 9.66 × 10−9 M、4.19 × 10−9 M 和 7.2 × 10−9 M，使用差分脉冲伏安法获得。开发的传感器可以在显着不同的电位下同时检测三种（布洛芬和吲哚美辛）中的两种，并在再生步骤后表现出显着的重现性。