Inquiry into relationships between energy metabolism and brain function requires a uniquely interdisciplinary mindset, and implementation of anti-aging lifestyle strategies based on this work also involves consistent mental and physical discipline. Dr. Mark P. Mattson embodies both of these qualities, based on the breadth and depth of his work on neurobiological responses to energetic stress, and on his own diligent practice of regular exercise and caloric restriction. Dr. Mattson created a neurotrophic niche in his own laboratory, allowing trainees to grow their skills, form new connections, and eventually migrate, forming their own labs while remaining part of the extended lab family. In this historical review, we highlight Dr. Mattson's many contributions to understanding neurobiological responses to physical exercise and dietary restriction, with an emphasis on the mechanisms that may underlie neuroprotection in ageing and age-related disease. On the occasion of Dr. Mattson's retirement from the National Institute on Aging, we highlight his foundational work on metabolism and neuroplasticity by reviewing the context for these findings and considering their impact on future research on the neuroscience of aging.

探究能量代谢与大脑功能之间的关系需要独特的跨学科思维，而基于这项工作的抗衰老生活方式策略的实施也需要始终如一的精神和身体纪律。Mark P. Mattson 博士体现了这两种品质，这基于他对高能压力的神经生物学反应工作的广度和深度，以及他自己勤奋的定期锻炼和热量限制实践。Mattson 博士在他自己的实验室中创建了一个神经营养学领域，使学员能够提高技能、建立新的联系并最终迁移，形成自己的实验室，同时保留扩展实验室大家庭的一部分。在这篇历史回顾中，我们重点介绍了马特森博士 对理解对体育锻炼和饮食限制的神经生物学反应做出了许多贡献，重点是可能构成衰老和与年龄相关疾病的神经保护的机制。在马特森博士从国家衰老研究所退休之际，我们通过回顾这些发现的背景并考虑它们对未来衰老神经科学研究的影响来强调他在新陈代谢和神经可塑性方面的基础工作。