Abstract Two new Co(II)-based coordination polymers {[Co(L)](DMF)} n ( 1 , H 2 L = 5-(1H-imidazol-1-yl)isophthalic acid) and {[Co 2 (L) 2 (H 2 O)]·3H 2 O} n ( 2 ) are successfully synthesized by the hydrothermal or solvothermal method. The resulting single crystal X-ray diffraction studies demonstrate that complex 1 presents a 3D 3,6-connected framework with a binuclear Co(II) paddle-wheel cluster as the secondary building unit, while complex 2 displays a 3,3,4,8-connected 3D network structure with the a trinuclear linear Co 3 (CO 2 ) 6 cluster as the secondary building unit. The in vivo local anesthesia activity of compounds 1 and 2 is evaluated via the mice hot plate analgesic experiment. Then, the local content of acetylcholine in mice is measured by the ELISA assay.

中文翻译：

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两种新的基于 Co(II) 的配位聚合物：晶体结构和由于减少局部乙酰胆碱含量而产生的局部镇痛活性

摘要 两种新型 Co(II) 基配位聚合物 {[Co(L)](DMF)} n ( 1 , H 2 L = 5-(1H-imidazol-1-yl)isophthalic acid) 和 {[Co 2 ( L) 2 (H 2 O)]·3H 2 O} n ( 2 ) 均采用水热法或溶剂热法成功合成。由此产生的单晶 X 射线衍射研究表明，复合物 1 呈现出 3D 3,6 连接的框架，其中双核 Co(II) 桨轮簇作为辅助构建单元，而复合物 2 显示出 3,3,4,以三核线性Co 3 (CO 2 ) 6 簇为二级构建单元的8-连通3D网络结构。通过小鼠热板镇痛实验评价化合物1和2的体内局部麻醉活性。然后，通过ELISA测定测量小鼠体内乙酰胆碱的局部含量。