Two new coordination complexes formulated as [Co(pbib)2(SO4)] (1) and [Cd(ppda)(pbib)(H2O)] (2, H2ppda = 1,4-phenylene-diacetic acid, pbib = 1,4-bis(1-imidazoly)benzene) are successfully prepared by a reaction of the pbib ligand with different metal salts and organic carboxylate ligands under the solvothermal reaction conditions. Furthermore, the treatment effect of compounds 1 and 2 on acute bacterial sinusitis (ABS) in vitro and in vivo is evaluated. Firstly, after treating with compounds 1 and 2, the bacterial growth curves of methicillin-resistant Staphylococcus aureus (MRSA) are measured. Moreover, the ELISA detection kit is applied after treatment with the compound to determine the inflammatory cytokines concentration in the blood.

中文翻译：

---

两种新的基于 Co(II) 的配位聚合物：晶体结构和通过抑制 MRSA 细菌生长对急性细菌性鼻窦炎的治疗活性

两种新的配位配合物被公式化为 [Co(pbib)2(SO4)] (1) 和 [Cd(ppda)(pbib)(H2O)] (2, H2ppda = 1,4-苯二乙酸, pbib = 1, 4-双(1-咪唑基)苯)是通过pbib配体与不同金属盐和有机羧酸盐配体在溶剂热反应条件下反应成功制备的。此外，还评估了化合物 1 和 2 在体外和体内对急性细菌性鼻窦炎 (ABS) 的治疗效果。首先，用化合物1和2处理后，测定耐甲氧西林金黄色葡萄球菌(MRSA)的细菌生长曲线。此外，在用该化合物处理后应用ELISA检测试剂盒来测定血液中的炎性细胞因子浓度。