Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes. Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange. MSC-derived exosomes (MSC-Exos) have potential for cell-free therapy for diseases of, for instance, the kidney, liver, heart, nervous system, and musculoskeletal system. Hence, MSC-Exos are an alternative to MSC-based therapy for regenerative medicine. We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries.

中文翻译：

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间充质干细胞来源的外泌体：再生医学的无细胞治疗策略。

间充质干细胞（MSCs）是多能干细胞，由于其强大的免疫抑制和再生能力，具有显着的再生医学潜力。MSC的治疗作用部分基于它们在称为外泌体的细胞外囊泡中生物活性因子的分泌。外泌体的直径为30-100 nm，介导细胞间通讯和物质交换。MSC衍生的外泌体（MSC-Exos）具有无细胞疗法的潜力，可用于治疗肾脏，肝脏，心脏，神经系统和肌肉骨骼系统等疾病。因此，MSC-Exos是基于MSC的再生医学疗法的替代方案。我们回顾了MSC-Exos及其在多种疾病和伤害中的治疗潜力。