Mesenchymal stem cells (MSCs) have been reported to possess immune regulatory effects in innate and adaptive immune reactions. MSCs can mediate intercellular communications by releasing extracellular vesicles (EVs), which deliver functional molecules to targeted cells. MSC derived EVs (MSC-EVs) confer altering effects on many immune cells, including T lymphocytes, B lymphocytes, natural killer cells, dendritic cells, and macrophages. A large number of studies have suggested that MSC-EVs participate in regulating autoimmunity related diseases. This characteristic of MSC-EVs makes them be potential biomarkers for the diagnosis and treatment of autoimmunity related diseases.

中文翻译：

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间充质干细胞衍生的细胞外囊泡在自身免疫中的作用：系统综述。

据报道，间充质干细胞（MSC）在先天性和适应性免疫反应中具有免疫调节作用。MSC可以通过释放细胞外小泡（EVs）来介导细胞间通讯，而这些小泡将功能分子传递到目标细胞。MSC衍生的EV（MSC-EV）对许多免疫细胞（包括T淋巴细胞，B淋巴细胞，自然杀伤细胞，树突状细胞和巨噬细胞）产生改变作用。大量研究表明，MSC-EV参与调节自身免疫性相关疾病。MSC-EVs的这一特性使它们成为诊断和治疗自身免疫性相关疾病的潜在生物标志物。