The relationship between sleep and brain lesions remains unknown in patients with multiple sclerosis (MS) and is currently under investigation. Sleep deprivation and reduction in the quality of sleep occur as a result of the direct involvement of the specific central nervous system structure. Therefore, we investigated the relationship between demyelination locations and sleep parameters such as sleep efficiency and respiratory disorders. The polysomnography measurements and brain magnetic resonance imaging (MRI) of 28 patients with relapsing–remitting MS were examined. The MRI results were evaluated using standardized maps to depict voxel-wise probability distribution of demyelination lesion load for patients. First, supratentorial and infratentorial lesion loads were evaluated. Subsequently, the procedure was completed by measuring the lobes and brainstem lesions loads in the brain. There was a negative correlation between the percentage of REM (%) and infratentorial and brainstem lesion loads ( $$\rho$$ : − 0.396, − 0.418; p 0.05). Although sleep-related breathing disorders are commonly seen in MS, this study shows that the polysomnography parameter most affected by brain lesion load distribution is REM sleep.

中文翻译：

---

多发性硬化患者脑部病变位置与睡眠参数的关联：一项初步研究

在多发性硬化症 (MS) 患者中，睡眠与大脑病变之间的关系仍然未知，目前正在调查中。由于特定中枢神经系统结构的直接参与，导致睡眠剥夺和睡眠质量下降。因此，我们研究了脱髓鞘位置与睡眠参数（如睡眠效率和呼吸系统疾病）之间的关系。检查了 28 名复发缓解型 MS 患者的多导睡眠图测量值和脑磁共振成像 (MRI)。使用标准化地图评估 MRI 结果，以描绘患者脱髓鞘病变负荷的体素概率分布。首先，评估幕上和幕下病变负荷。随后，该过程是通过测量大脑中的叶和脑干病变负荷来完成的。REM 的百分比 (%) 与幕下和脑干病变负荷之间存在负相关 ($$\rho$$ : − 0.396, − 0.418; p = 0.05)。尽管与睡眠相关的呼吸障碍在 MS 中很常见，但这项研究表明，受脑损伤负荷分布影响最大的多导睡眠图参数是 REM 睡眠。