The aim of the study was to evaluate whether there was a problem in the interneuronal junctions of patients with central sleep apnea using the blink reflex test. Twenty-one (21) patients with central type apneas and/or hipopneas and 21 controls were recruited. The blink reflex test was performed and R1, R2 and contralateral R2 (R3) wave values of both groups were recorded in milliseconds (ms). The results of blink test in patients with central sleep apnea were right side R1 = 9.45 ± 4.35 ms, R2 = 33.35 ± 9.97 ms, R3 = 32.15 ± 10.05 ms and left side R1 = 9.90 ± 3.82 ms, R2 = 31.5 ± 10.5 ms, R3 = 29.00 ± 4.77 ms, (p = 0.49, p = 0.69, p = 0.60, respectively), whereas the results of blink test in controls were right side R1 = 9.25 ± 3.50 ms, R2 = 32.75 ± 11.4 ms, R3 = 32.50 ± 13.12 ms and left side R1 = 7.35 ± 2.6 ms, R2 = 27.75 ± 9.75 ms, R3 = 26.65 ± 14.5 ms. (p = 0.015, p = 0.04, p = 0.035, respectively). All left side (R1, R2, R3) blink reflex of the patients with central sleep apnea was statistically significant prolonged than controls. However, there was no statistically significant difference between women with central sleep apnea and controls regarding all right side (R1, R2, R3) blink reflex. There was statistically significant difference in R1, R2 and R3 waves of left sides blink reflex between two groups. The results may be related to central nervous system damage or/and degeneration in the interneuronal junctions of the brain stem in patients with central sleep apnea syndrome.

中文翻译：

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中枢性睡眠呼吸暂停综合征患者的眨眼测试结果

该研究的目的是使用眨眼反射测试评估中枢性睡眠呼吸暂停患者的神经元间连接是否存在问题。招募了二十一 (21) 名患有中枢性呼吸暂停和/或髋部呼吸暂停的患者和 21 名对照。进行瞬目反射试验，以毫秒（ms）为单位记录两组的R1、R2和对侧R2（R3）波值。中枢性睡眠呼吸暂停患者眨眼测试结果右侧R1=9.45±4.35ms，R2=33.35±9.97ms，R3=32.15±10.05ms，左侧R1=9.90±3.82ms，R2=31.5ms。 , R3 = 29.00 ± 4.77 ms, (分别为 p = 0.49, p = 0.69, p = 0.60), 而对照组眨眼测试的结果为右侧 R1 = 9.25 ± 3.50 ms, R2 = 32.75 ± 11.4 ms, R3 = 32.50 ± 13.12 ms，左侧 R1 = 7.35 ± 2.6 ms，R2 = 27.75 ± 9.75 ms，R3 = 26。65 ± 14.5 毫秒。（分别为 p = 0.015、p = 0.04、p = 0.035）。中枢性睡眠呼吸暂停患者的所有左侧（R1、R2、R3）眨眼反射均比对照组延长，具有统计学意义。然而，在所有右侧（R1、R2、R3）眨眼反射方面，患有中枢性睡眠呼吸暂停的女性和对照组之间没有统计学上的显着差异。两组左侧眨眼反射的R1、R2、R3波差异有统计学意义。结果可能与中枢性睡眠呼吸暂停综合征患者脑干神经元间连接处的中枢神经系统损伤或/和退化有关。在所有右侧（R1、R2、R3）眨眼反射方面，患有中枢性睡眠呼吸暂停的女性和对照组之间没有统计学上的显着差异。两组左侧眨眼反射的R1、R2、R3波差异有统计学意义。结果可能与中枢性睡眠呼吸暂停综合征患者脑干神经元间连接处的中枢神经系统损伤或/和退化有关。在所有右侧（R1、R2、R3）眨眼反射方面，患有中枢性睡眠呼吸暂停的女性和对照组之间没有统计学上的显着差异。两组左侧眨眼反射的R1、R2、R3波差异有统计学意义。结果可能与中枢性睡眠呼吸暂停综合征患者脑干神经元间连接处的中枢神经系统损伤或/和退化有关。