Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain barrier (BBB) permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM. Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related increase in BBB permeability, including with formation of brain edema. The meningeal lymphatic system plays a crucial role in the mechanism of brain drainage and clearance from metabolites and toxic molecules. We discuss that noninvasive photonic stimulation of fluid clearance via meningeal lymphatic vessels, and application of optical coherence tomography (OCT) for bed-side monitoring of meningeal lymphatic drainage has the promising perspective to be widely applied in both experimental and clinical studies of PDT and improving guidelines of PDT of brain tumors.

中文翻译：

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脑肿瘤的光动力疗法和用于体内监测脑流体动力学的新型光学相干断层扫描策略

光动力疗法 (PDT) 是一种有前途的工具，可用于治疗脑肿瘤的微创替代方法。新发现的 PDT 诱导的血脑屏障 (BBB) 通透性开放开启了胶质母细胞瘤 GBM 手术后治疗中药物脑递送的新策略。在这里，我们讨论了 PDT 介导的 BBB 开放机制和 PDT 相关的 BBB 通透性增加的年龄差异，包括脑水肿的形成。脑膜淋巴系统在脑引流和清除代谢物和有毒分子的机制中起着至关重要的作用。我们讨论了通过脑膜淋巴管对液体清除的无创光子刺激，