Abstract

The effects of different regimens (morning and evening) of melatonin administration (30 mg/kg/day during 7 weeks) on the course of inflammation processes in visceral white adipose tissue (the presence of macrophages that formed crown-like structures around the adipocytes, fibrosis level and mast cell numbers in white adipose tissue, and the content of proinflammatory (IL-1β, IL-8, tumor necrosis factor α, and interferon γ) and anti-inflammatory (IL-4 and IL-10) cytokines in blood serum) was analyzed in rats with obesity induced by a high-calorie diet. Melatonin administration was followed by changes in the numbers of macrophages and mast cells in white adipose tissue of obese rats, and decreases of collagen fiber content (fibrosis) and the area of adipocytes were also demonstrated. Melatonin administration in the evening (1 h before the lights off) turned out to be more efficient than the morning administration (1 h after the lights on). Moreover, the level of anti-inflammatory cytokines increased in the blood serum of obese rats after melatonin administration, whereas the level of proinflammatory cytokines decreased at the same time. This demonstrates the anti-inflammatory effects of melatonin in the context of obesity development and serves as a theoretical prerequisite for further consideration of the possible use of melatonin in obesity treatment.

中文翻译：

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不同褪黑素给药方案的饮食诱导型肥胖大鼠白色脂肪组织中炎症状态的变化

摘要

服用褪黑激素的不同方案（早上和晚上）（7周内每天30 mg / kg /天）对内脏白色脂肪组织炎症过程的影响（巨噬细胞的存在在脂肪细胞周围形成冠状结构，脂肪组织中纤维化水平和肥大细胞数量，以及血液中促炎（IL-1β，IL-8，肿瘤坏死因子α和干扰素γ）和抗炎（IL-4和IL-10）细胞因子的含量在高热量饮食诱导的肥胖大鼠中进行了分析）。褪黑素给药后，肥胖大鼠白色脂肪组织中巨噬细胞和肥大细胞数量发生变化，胶原蛋白含量（纤维化）和脂肪细胞面积减少。事实证明，晚上（开灯前1小时）服用褪黑激素比早上（开灯后1小时）服用更为有效。此外，褪黑激素给药后，肥胖大鼠血清中的抗炎细胞因子水平升高，而促炎细胞因子水平同时下降。这证明了褪黑素在肥胖症发展中的抗炎作用，并为进一步考虑褪黑激素在肥胖症治疗中的使用提供了理论前提。而促炎细胞因子的水平同时下降。这证明了褪黑激素在肥胖症发展中的抗炎作用，并为进一步考虑在治疗肥胖症中使用褪黑激素提供了理论前提。而促炎细胞因子的水平同时下降。这证明了褪黑素在肥胖症发展中的抗炎作用，并为进一步考虑褪黑激素在肥胖症治疗中的使用提供了理论前提。