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Changes in the Inflammatory Status in White Adipose Tissue of Rats with Diet-Induced Obesity at Different Regimens of Melatonin Administration
Cytology and Genetics ( IF 0.5 ) Pub Date : 2020-02-10 , DOI: 10.3103/s0095452720010077 O. O. Kalmukova , A. V. Yurchenko , A. M. Savchuk , M. E. Dzerzhynsky
中文翻译:
不同褪黑素给药方案的饮食诱导型肥胖大鼠白色脂肪组织中炎症状态的变化
更新日期:2020-02-10
Cytology and Genetics ( IF 0.5 ) Pub Date : 2020-02-10 , DOI: 10.3103/s0095452720010077 O. O. Kalmukova , A. V. Yurchenko , A. M. Savchuk , M. E. Dzerzhynsky
Abstract
The effects of different regimens (morning and evening) of melatonin administration (30 mg/kg/day during 7 weeks) on the course of inflammation processes in visceral white adipose tissue (the presence of macrophages that formed crown-like structures around the adipocytes, fibrosis level and mast cell numbers in white adipose tissue, and the content of proinflammatory (IL-1β, IL-8, tumor necrosis factor α, and interferon γ) and anti-inflammatory (IL-4 and IL-10) cytokines in blood serum) was analyzed in rats with obesity induced by a high-calorie diet. Melatonin administration was followed by changes in the numbers of macrophages and mast cells in white adipose tissue of obese rats, and decreases of collagen fiber content (fibrosis) and the area of adipocytes were also demonstrated. Melatonin administration in the evening (1 h before the lights off) turned out to be more efficient than the morning administration (1 h after the lights on). Moreover, the level of anti-inflammatory cytokines increased in the blood serum of obese rats after melatonin administration, whereas the level of proinflammatory cytokines decreased at the same time. This demonstrates the anti-inflammatory effects of melatonin in the context of obesity development and serves as a theoretical prerequisite for further consideration of the possible use of melatonin in obesity treatment.中文翻译:
不同褪黑素给药方案的饮食诱导型肥胖大鼠白色脂肪组织中炎症状态的变化