当前位置：
X-MOL 学术
›
Polym. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Antibacterial properties of synthesized cyclic and linear cationic copolymers
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020-09-21 , DOI: 10.1039/d0py00755b Jinbao Xu 1, 2, 3, 4, 5 , Lu Pu 6, 7, 8 , Jielin Ma 6, 7, 8 , Sagar Kundan Kumar 6, 7, 8 , Hongwei Duan 6, 7, 8
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020-09-21 , DOI: 10.1039/d0py00755b Jinbao Xu 1, 2, 3, 4, 5 , Lu Pu 6, 7, 8 , Jielin Ma 6, 7, 8 , Sagar Kundan Kumar 6, 7, 8 , Hongwei Duan 6, 7, 8
Affiliation
|
Cationic polymers are one of the main classes of materials investigated against bacteria through the membrane-lysis mechanism. The cationic–hydrophobic balance, molecular structure and distribution of cationic and hydrophobic moieties of these polymers are known to have a major effect on the antimicrobial activity. We have synthesized cyclic poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) based copolymers with various components by the intra-chain click cyclization of α-alkyne-ω-azido hetero-difunctional linear precursors prepared via atom transfer radical polymerization (ATRP). Copolymers were characterized by GPC, FT-IR and NMR to confirm efficient cyclization. Cyclic cationic copolymers with smaller hydrodynamic volumes and compact structures attracted by negatively charged bacterial cell membranes cause membrane disruption much more easily compared to their linear analogues, showing better antibacterial performance than their linear counterparts. In addition, the cytotoxicities of the cyclic cationic copolymers were also a little lower than those of their linear copolymers.
中文翻译：
合成的环状和线性阳离子共聚物的抗菌性能
阳离子聚合物是通过膜裂解机制研究的针对细菌的主要材料之一。已知这些聚合物的阳离子-疏水平衡，分子结构以及阳离子和疏水部分的分布对抗菌活性有重要影响。我们已经通过α-炔烃-ω-叠氮基杂双功能线性前体的链内点击环化反应合成了具有各种组分的环状聚甲基丙烯酸2-（二甲基氨基）乙酯（PDMAEMA）基共聚物。原子转移自由基聚合（ATRP）。通过GPC，FT-IR和NMR对共聚物进行了表征，以确认有效的环化作用。与线性类似物相比，具有较小流体力学体积和紧凑结构的环状阳离子共聚物被带负电荷的细菌细胞膜吸引，导致膜破裂更容易，显示出更好的抗菌性能。另外，环状阳离子共聚物的细胞毒性也比其线性共聚物的细胞毒性低一些。
更新日期：2020-10-02
中文翻译：
合成的环状和线性阳离子共聚物的抗菌性能
阳离子聚合物是通过膜裂解机制研究的针对细菌的主要材料之一。已知这些聚合物的阳离子-疏水平衡，分子结构以及阳离子和疏水部分的分布对抗菌活性有重要影响。我们已经通过α-炔烃-ω-叠氮基杂双功能线性前体的链内点击环化反应合成了具有各种组分的环状聚甲基丙烯酸2-（二甲基氨基）乙酯（PDMAEMA）基共聚物。原子转移自由基聚合（ATRP）。通过GPC，FT-IR和NMR对共聚物进行了表征，以确认有效的环化作用。与线性类似物相比，具有较小流体力学体积和紧凑结构的环状阳离子共聚物被带负电荷的细菌细胞膜吸引，导致膜破裂更容易，显示出更好的抗菌性能。另外，环状阳离子共聚物的细胞毒性也比其线性共聚物的细胞毒性低一些。
京公网安备 11010802027423号