Curcumin, isolated from the rhizome of Curcuma longa, is one of the most extensively studied phytochemicals. This natural compound has a variety of pharmacological effects including antioxidant, anti-inflammatory, anti-tumor, cardio-protective, hepato-protective and anti-diabetic. Wnt signaling pathway, one of the potential targets of curcumin through upregulation and/or downregulation, plays a significant role in many diseases, even in embryogenesis and development of various organs and systems. In order to exert an anti-tumor activity in the organism, curcumin seems to inhibit the Wnt pathway. The downstream mediators of Wnt signaling pathway such as c-Myc and cyclin D1 are also modified by curcumin. This review demonstrates how curcumin influences the Wnt signaling pathway and is beneficial for the treatment of neurological disorders (Alzheimer’s and Parkinson’s diseases), cancers (melanoma, lung cancer, breast cancer, colon cancer, endothelial carcinoma, gastric carcinoma and hepatocellular carcinoma) and other diseases, such as diabetes mellitus or bone disorders.

从姜黄的根茎中分离出的姜黄素是研究最广泛的植物化学物质之一。这种天然化合物具有多种药理作用，包括抗氧化剂，抗炎药，抗肿瘤药，心脏保护药，肝保护药和抗糖尿病药。Wnt信号通路是姜黄素通过上调和/或下调的潜在靶标之一，在许多疾病中，甚至在胚胎发生和各种器官和系统的发育中，都起着重要作用。为了在生物体中发挥抗肿瘤活性，姜黄素似乎抑制了Wnt途径。Wnt信号通路的下游介质，如c-Myc和细胞周期蛋白D1也被姜黄素修饰。