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Cyclometalated Iridium(III) Complexes as High-Sensitivity Two-Photon Excited Mitochondria Dyes and Near-Infrared Photodynamic Therapy Agents.
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-09-20 , DOI: 10.1021/acs.inorgchem.0c01509 Xu-Dan Bi 1 , Rong Yang 1 , Yue-Chen Zhou 1 , Daomei Chen 2 , Guo-Kui Li 1 , Yuan-Xiao Guo 1 , Meng-Fan Wang 1 , Dandan Liu 3 , Feng Gao 1
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-09-20 , DOI: 10.1021/acs.inorgchem.0c01509 Xu-Dan Bi 1 , Rong Yang 1 , Yue-Chen Zhou 1 , Daomei Chen 2 , Guo-Kui Li 1 , Yuan-Xiao Guo 1 , Meng-Fan Wang 1 , Dandan Liu 3 , Feng Gao 1
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Photodynamic therapy (PDT) using two-photon near-infrared light excitation is a very effective way to avoid the use of short-wavelength ultraviolet or visible light which cannot efficiently penetrate into the biological tissues and is harmful to the healthy cells. Herein, a series of cyclometalated Ir(III) complexes with a structurally simple diimine ligand were designed and the synthetic route and preparation procedure were optimized, so that the complexes could be obtained in apparently higher yield, productivity, and efficiency in comparison to the traditional methods. Their ground state and excited singlet and triplet state properties were studied by spectroscopy and quantum chemistry theoretical calculations to investigate the effect of substituent groups on the photophysical properties of the complexes. The Ir(III) complexes, especially Ir1 and Ir3, showed very low dark toxicities and high phototoxicities under both one-photon and two-photon excitation, indicating their great potential as PDT agents. They were also found to be highly sensitive two-photon mitochondria dyes.
中文翻译：
环金属化铱（III）络合物作为高灵敏度双光子激发的线粒体染料和近红外光动力疗法药物。
使用双光子近红外光激发的光动力疗法（PDT）是避免使用短波紫外线或可见光的一种非常有效的方法，该短波紫外线或可见光无法有效地渗透到生物组织中并对健康细胞有害。在此，设计了一系列具有结构简单的二亚胺配体的环金属化的Ir（III）配合物，并优化了合成路线和制备步骤，从而与传统方法相比，可以明显提高收率，生产率和效率。方法。通过光谱学和量子化学理论计算研究了它们的基态以及激发的单重态和三重态的性质，以研究取代基对配合物光物理性质的影响。Ir（III）配合物，尤其是Ir1和Ir3在单光子和双光子激发下均显示出极低的暗毒性和高光毒性，表明它们具有作为PDT试剂的巨大潜力。还发现它们是高度敏感的两光子线粒体染料。
更新日期：2020-10-21
中文翻译：
环金属化铱（III）络合物作为高灵敏度双光子激发的线粒体染料和近红外光动力疗法药物。
使用双光子近红外光激发的光动力疗法（PDT）是避免使用短波紫外线或可见光的一种非常有效的方法，该短波紫外线或可见光无法有效地渗透到生物组织中并对健康细胞有害。在此，设计了一系列具有结构简单的二亚胺配体的环金属化的Ir（III）配合物，并优化了合成路线和制备步骤，从而与传统方法相比，可以明显提高收率，生产率和效率。方法。通过光谱学和量子化学理论计算研究了它们的基态以及激发的单重态和三重态的性质，以研究取代基对配合物光物理性质的影响。Ir（III）配合物，尤其是Ir1和Ir3在单光子和双光子激发下均显示出极低的暗毒性和高光毒性，表明它们具有作为PDT试剂的巨大潜力。还发现它们是高度敏感的两光子线粒体染料。
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