Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes,ACS Sustainable Chemistry & Engineering

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Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-09-21 , DOI: 10.1021/acssuschemeng.0c04950
Aaron S. McCalmont ₁ , Amalia Ruiz ₂ , M. Cristina Lagunas ₁ , Wafa T. Al-Jamal ₂ , Deborah E. Crawford ₃

Affiliation

Despite evidence that mechanochemistry has the potential to be a revolutionary manufacturing technique, the Pharma industry is still reluctant to introduce these new technologies into their manufacturing processes. Therefore, it is now time to pioneer the implementation of mechanochemistry in industry, by analyzing the bioactive and physicochemical properties of mechanochemical products. Herein, we report the mechanochemical synthesis of a Cu(II) metallodrug that has been previously investigated in the solution. Interestingly, we found that ball milling leads to the formation of a novel Cu(II) complex of octahedral geometry, whereas conventional synthesis resulted in a square-pyramidal complex. In addition, we report for the first time, the enhanced cytotoxicity of this Cu(II) metallodrug, toward ovarian cancer cell lines, as a result of its mechanochemical preparation.

中文翻译：

机械化学制备的Cu（II）配合物的细胞毒性

尽管有证据表明机械化学有潜力成为一种革命性的制造技术，但制药业仍然不愿意将这些新技术引入其制造过程。因此，现在是时候通过分析机械化学产品的生物活性和物理化学特性，在工业中率先实施机械化学。在此，我们报告了先前已在溶液中研究过的Cu（II）金属药物的机械化学合成。有趣的是，我们发现球磨导致八面体几何形状的新型Cu（II）络合物的形成，而常规合成产生了方形-金字塔形络合物。此外，我们首次报告了这种Cu（II）金属药物对卵巢癌细胞系增强的细胞毒性，

更新日期：2020-10-12

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