STUDY OBJECTIVE To prospectively examine the association between sleep quality and incident cancer risk in the elderly. METHODS A total of 10036 participants aged ≥50 years free of cancer at baseline from the English Longitudinal Study of Ageing (ELSA) at wave 4 (2008) were included, and followed up until 2016. The primary endpoint was new onset physician-diagnosed cancer. Sleep quality was assessed by four questions regarding the frequency of sleep problems and overall subjective feeling of sleep quality in the last month, with higher score denoting poorer sleep quality. The multivariable Cox regression model was used to calculate hazard ratio (HR) with 95% confidence interval (CI) for incident cancer risk according to sleep quality. RESULTS At 8-year follow up, a total of 745 (7.4%) participants developed cancer. Compared with good sleep quality at baseline, HR (95% CI) for incident cancer risk was 1.328 (1.061, 1.662) for intermediate quality, 1.586 (1.149, 2.189) for poor quality. Similarly, compared with maintaining good sleep quality in the first four years, HR (95% CI) for incident cancer risk was 1.615 (1.208, 2.160) for maintaining intermediate quality and 1.608 (1.043, 2.480) for maintaining poor quality. The exclusion of participants with family history of cancer or abnormal sleep duration yielded consistent results. CONCLUSIONS Poor sleep quality is positively associated with the long-term risk of developing cancer in an elderly cohort. Both medical staffs and the general public should pay more attention to improving sleep hygiene.

中文翻译：

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睡眠质量和癌症风险——来自英国老龄化纵向研究的结果

研究目的前瞻性研究老年人睡眠质量与癌症发病风险之间的关联。方法 共有 10036 名年龄≥50 岁的基线无癌症参与者（2008 年英国老龄化纵向研究（ELSA））被纳入，并随访至 2016 年。主要终点是新发的医生诊断的癌症. 睡眠质量通过上个月睡眠问题发生频率和睡眠质量总体主观感受四个问题进行评估，得分越高表示睡眠质量越差。多变量 Cox 回归模型用于根据睡眠质量计算癌症发生风险的风险比 (HR) 和 95% 置信区间 (CI)。结果 在 8 年的随访中，共有 745 (7.4%) 名参与者患上了癌症。与基线时良好的睡眠质量相比，中等质量的新发癌症风险的 HR (95% CI) 为 1.328 (1.061, 1.662)，质量差的为 1.586 (1.149, 2.189)。类似地，与前四年保持良好睡眠质量相比，保持中等质量的新发癌症风险 HR (95% CI) 为 1.615 (1.208, 2.160)，保持较差质量的 HR (95% CI) 为 1.608 (1.043, 2.480)。排除有癌症家族史或睡眠时间异常的参与者产生了一致的结果。结论 在老年人群中，睡眠质量差与患癌症的长期风险呈正相关。无论是医务人员还是普通民众，都应该更加注意改善睡眠卫生。189）质量差。类似地，与前四年保持良好睡眠质量相比，保持中等质量的新发癌症风险 HR (95% CI) 为 1.615 (1.208, 2.160)，保持较差质量的 HR (95% CI) 为 1.608 (1.043, 2.480)。排除有癌症家族史或睡眠时间异常的参与者产生了一致的结果。结论 在老年人群中，睡眠质量差与患癌症的长期风险呈正相关。无论是医务人员还是普通民众，都应该更加注意改善睡眠卫生。189）质量差。类似地，与前四年保持良好睡眠质量相比，保持中等质量的新发癌症风险 HR (95% CI) 为 1.615 (1.208, 2.160)，保持较差质量的 HR (95% CI) 为 1.608 (1.043, 2.480)。排除有癌症家族史或睡眠时间异常的参与者产生了一致的结果。结论 在老年人群中，睡眠质量差与患癌症的长期风险呈正相关。无论是医务人员还是普通民众，都应该更加注意改善睡眠卫生。排除有癌症家族史或睡眠时间异常的参与者产生了一致的结果。结论 在老年人群中，睡眠质量差与患癌症的长期风险呈正相关。无论是医务人员还是普通民众，都应该更加注意改善睡眠卫生。排除有癌症家族史或睡眠时间异常的参与者产生了一致的结果。结论 在老年人群中，睡眠质量差与患癌症的长期风险呈正相关。无论是医务人员还是普通民众，都应该更加注意改善睡眠卫生。