Extensive research has gone into proposing a promising link between melatonin administration and attenuation of epileptic activity, the majority of which suggest its propensity as an antiseizure with antioxidant and neuroprotective properties. In the past few years, a number of studies highlighting the association of the melatonergic ligands with epilepsy have also emerged. In this context, our review is based on discussing the recent studies and various mechanisms of action that the said category of drugs exhibit in the context of being therapeutically viable antiseizure drugs. Our search revealed several articles on the four major drugs i.e. melatonin, agomelatine, ramelteon and piromelatine along with other melatonergic agonists like tasimelteon and TIK-301. Our review is suggestive of antiseizure effects of both melatonin and its analogues; however, extensive research work is still required to study their implications in the treatment of persons with epilepsy. Further evaluation of melatonergic signaling pathways and mechanisms may prove to be helpful in the near future and might prove to be a significant advance in the field of epileptology.

中文翻译：

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褪黑激素及其类似物在癫痫中的作用。


广泛的研究表明褪黑激素的施用和癫痫活动的减弱之间存在着有希望的联系，其中大多数研究表明它倾向于作为具有抗氧化和神经保护特性的抗癫痫药物。在过去的几年中，也出现了一些强调褪黑激素配体与癫痫之间关系的研究。在这种情况下，我们的综述基于讨论最近的研究以及上述类别的药物在治疗上可行的抗癫痫药物方面所表现出的各种作用机制。我们的搜索发现了几篇关于四种主要药物（即褪黑激素、阿戈美拉汀、雷美替胺和吡美拉汀）以及其他褪黑激素激动剂（如他司美琼和 TIK-301）的文章。我们的评论表明褪黑激素及其类似物具有抗癫痫作用；然而，仍需要开展大量研究工作来研究其对癫痫患者治疗的影响。对褪黑激素信号通路和机制的进一步评估可能在不久的将来有所帮助，并且可能被证明是癫痫学领域的重大进步。