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Low expression of adenomatous polyposis coli 2 correlates with aggressive features and poor prognosis in colorectal cancer.
Bioengineered ( IF 4.2 ) Pub Date : 2020-09-20 , DOI: 10.1080/21655979.2020.1820823
Yan Sun 1 , Hua Tian 2 , Xuehu Xu 3 , Lin Wang 4
Affiliation  

Currently, there are no relevant findings on the diagnostic and prognostic roles of adenomatous polyposis coli 2 (APC2) in colorectal cancer (CRC). This study investigated the clinical value of APC2 dysregulation in the prognosis of CRC. Immunohistochemical scores obtained from tissue microarrays were used to quantify the expression of APC2 protein in 201 CRC tissues and 139 adjacent normal tissues. A chi-squared test was performed to analyze the association between APC2 expression and various clinical characteristics. Differences in 5-year survival between groups were analyzed. A receiver operating characteristic (ROC) curve was generated to investigate the potential association between APC2 and CRC diagnosis. Compared with adjacent normal tissues, APC2 was downregulated in CRC tissues (P = 0.0004). Survival analyses revealed that CRC patients with high APC2 expression (96.74%) obtained better 5-year survival rates than those with low APC2 expression (88.07%). CRC patients with low APC2 expression exhibited obvious lymphovascular invasion (P = 0.010), lymph node metastasis (P = 0.007), and high tumor node metastasis (TNM) stage (P = 0.007). Furthermore, ROC curves confirmed that APC2 was associated with lymphovascular invasion (P = 0.004), lymph node metastasis (P = 0.002), and TNM staging (P = 0.002). In summary, low APC2 expression in CRC tissues was associated with poor prognosis and may be a useful biomarker for the prognosis and clinical classification of CRC.



中文翻译:

腺瘤性息肉病大肠杆菌 2 的低表达与结直肠癌的侵袭性特征和不良预后相关。

目前,关于腺瘤性息肉病 2(APC2)在结直肠癌(CRC)中的诊断和预后作用尚无相关发现。本研究调查了 APC2 失调在 CRC 预后中的临床价值。从组织微阵列获得的免疫组织化学评分用于量化 201 个 CRC 组织和 139 个相邻正常组织中 APC2 蛋白的表达。进行卡方检验以分析 APC2 表达与各种临床特征之间的关联。分析了组间 5 年生存率的差异。生成受试者工作特征 (ROC) 曲线以研究 APC2 与 CRC 诊断之间的潜在关联。与邻近的正常组织相比,APC2 在 CRC 组织中下调(P = 0.0004)。生存分析显示,高 APC2 表达的 CRC 患者(96.74%)比低 APC2 表达的 CRC 患者(88.07%)获得更好的 5 年生存率。APC2低表达的CRC患者表现出明显的淋巴血管浸润(P=0.010)、淋巴结转移(P=0.007)和高肿瘤淋巴结转移(TNM)分期(P=0.007)。此外,ROC 曲线证实 APC2 与淋巴血管浸润(P = 0.004)、淋巴结转移(P = 0.002)和 TNM 分期(P = 0.002)相关。总之,结直肠癌组织中低 APC2 表达与不良预后相关,可能是结直肠癌预后和临床分类的有用生物标志物。APC2低表达的CRC患者表现出明显的淋巴血管浸润(P=0.010)、淋巴结转移(P=0.007)和高肿瘤淋巴结转移(TNM)分期(P=0.007)。此外,ROC 曲线证实 APC2 与淋巴血管浸润(P = 0.004)、淋巴结转移(P = 0.002)和 TNM 分期(P = 0.002)相关。总之,结直肠癌组织中低 APC2 表达与不良预后相关,可能是结直肠癌预后和临床分类的有用生物标志物。APC2低表达的CRC患者表现出明显的淋巴血管浸润(P=0.010)、淋巴结转移(P=0.007)和高肿瘤淋巴结转移(TNM)分期(P=0.007)。此外,ROC 曲线证实 APC2 与淋巴血管浸润(P = 0.004)、淋巴结转移(P = 0.002)和 TNM 分期(P = 0.002)相关。总之,结直肠癌组织中低 APC2 表达与不良预后相关,可能是结直肠癌预后和临床分类的有用生物标志物。

更新日期:2020-09-21
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