Background

MicroRNA (miR)-146a might participate in the occurrence of malignant tumor. The aim of the current investigation was to evaluate the relationship of microRNA-146a (miR-146a) rs2910164 C > G locus to the development of digestive system cancer (DSC).

Methods

We retrieved publications from PubMed, China Biology Medicine and EMBASE databases up to August 29, 2019. Finally, 56 independent case-control studies with 59,098 participants were included. The strength of the relationship between rs2910164 locus and a risk of DSC was assessed. The power value was also calculated in this study.

Results

We identified a correlation of rs2910164 locus in miR-146a with DSC development in dominant model (P = .035; power value = 0.994). MiR-146a rs2910164 locus was also identified to be correlated with a risk of DSC in Asians (GG/CG vs. CC: P = .033; power value = 0.989). Sensitivity analysis revealed that any individual study could not alter the final decision. In our study, no significant bias was found among these included studies (P > .1). The results of heterogeneity analysis suggested that small sample size (<1000 subjects), colorectal carcinoma, Asians, gastric carcinoma, esophageal squamous cell carcinoma, hepatocellular cancer, hospital-based study and high-quality score (≥7.0) subgroups contributed the heterogeneity to our findings. Galbraith radial plot determined that eleven outliers contributed to the main heterogeneity.

Conclusion

In summary, this meta-analysis highlights that rs2910164 locus might be implicated in the risk of DSC. More studies are, therefore, needed to confirm our results.

中文翻译：

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MiRNA-146a rs2910164 赋予消化系统癌症的易感性：一项涉及 59,098 名受试者的荟萃分析。

背景

MicroRNA ( miR ) -146a可能参与恶性肿瘤的发生。本研究的目的是评估microRNA-146a ( miR-146a ) rs2910164 C > G 基因座与消化系统癌 (DSC) 发展的关系。

方法

我们从 PubMed、China Biology Medicine 和 EMBASE 数据库中检索到截至 2019 年 8 月 29 日的出版物。最后，纳入了 56 项独立病例对照研究，共有 59,098 名参与者。评估了 rs2910164 基因座与 DSC 风险之间关系的强度。本研究还计算了功效值。

结果

我们确定了miR-146a中 rs2910164 基因座与显性模型中 DSC 发展的相关性（P = .035；功效值 = 0.994）。MiR-146a rs2910164 基因座也被确定与亚洲人的 DSC 风险相关（GG/CG 与 CC：P = .033；功效值 = 0.989）。敏感性分析表明，任何单独的研究都不能改变最终决定。在我们的研究中，在这些纳入的研究中未发现显着偏倚（P> .1)。异质性分析结果表明，小样本量（<1000 名受试者）、结直肠癌、亚洲人、胃癌、食管鳞状细胞癌、肝细胞癌、基于医院的研究和高质量评分（≥7.0）亚组对我们的发现。Galbraith 径向图确定 11 个异常值导致了主要的异质性。

结论

总之，这项荟萃分析强调 rs2910164 基因座可能与 DSC 的风险有关。因此，需要更多的研究来证实我们的结果。