Two synthetic approaches to enaminones fused to 1,4-benzothiazin-2-one moiety, which can be interesting in studies on biological activity, chemosensors, and fluorescence, were developed via the reaction of furan-2,3-diones or acylpyruvic acids in the presence of carbodiimides with o-aminothiophenols. The target enaminones were formed together with pharmaceutically interesting 2-hydroxy-2H-1,4-benzothiazin-3(4H)-ones. A selective synthetic approach to 2-hydroxy-2H-1,4-benzothiazin-3(4H)-ones was developed via the solvent-switchable reaction of furan-2,3-diones with o-aminothiophenol. Preliminary biological assays (antimicrobial, acute toxicity) of the new compounds were carried out.

中文翻译：

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由酰基丙酮酸或呋喃-2,3-二酮和邻氨基苯硫酚合成1,4-苯并噻嗪酮

通过呋喃-2,3-二酮或酰基丙酮酸的反应，开发了两种与1,4-苯并噻嗪-2-酮部分融合的烯胺酮的合成方法，这在生物学活性，化学传感器和荧光研究中可能是有趣的。碳二亚胺与邻氨基苯硫酚的存在。目标烯胺酮与可药用的2-羟基-2 H -1,4-苯并噻嗪-3（4 H）-one一起形成。通过呋喃-2,3-二酮与邻氨基硫酚的溶剂转换反应，开发了选择性合成2-羟基-2 H -1,4-苯并噻嗪-3（4 H）-的方法。进行了新化合物的初步生物学测定（抗菌，急性毒性）。