Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome,Neurogastroenterology & Motility

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Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-09-21 , DOI: 10.1111/nmo.13985
Marco Constante ₁ , Giada De Palma ₁ , Jun Lu ₁ , Jennifer Jury ₁ , Liam Rondeau ₁ , Alberto Caminero ₁ , Stephen M Collins ₁ , Elena F Verdu ₁ , Premysl Bercik ₁

Affiliation

Gnotobiotic mice colonized with microbiota from patients with irritable bowel syndrome (IBS) and comorbid anxiety (IBS+A) display gut dysfunction and anxiety‐like behavior compared to mice colonized with microbiota from healthy volunteers. Using this model, we tested the therapeutic potential of the probiotic yeast Saccharomyces boulardii strain CNCM I‐745 (S. bou) and investigated underlying mechanisms.

中文翻译：

Saccharomyces boulardii CNCM I-745 在肠易激综合征人源化小鼠模型中调节微生物群-肠-脑轴

与健康志愿者的微生物群定植的小鼠相比，肠道易激综合征 (IBS) 和共病焦虑 (IBS+A) 患者的微生物群定植的 Gnotobiotic 小鼠表现出肠道功能障碍和焦虑样行为。使用该模型，我们测试了益生菌酵母的治疗潜力布拉酵母菌株CNCM I-745（小号。 BOU）并调查潜在的机制。

更新日期：2020-09-21

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