Antimicrobial and biodegradable materials based on ε‐caprolactone derivatives,Journal of Applied Polymer Science

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Antimicrobial and biodegradable materials based on ε‐caprolactone derivatives
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-09-21 , DOI: 10.1002/app.49903
Feziwe Bathabile Mamba ₁ , Thando Ndlovu ₂ , Siyasanga Mbizana ₁ , Wesaal Khan ₂ , Nonjabulo Prudence Gule ₁

Affiliation

Appropriate wound care is pivotal in preventing wound and postsurgery infections, which remain a serious clinical problem. In this study, we report the successful fabrication of antimicrobial and biodegradable materials for possible use in the medical field. Amino functionalized polycaprolactone (PCL [Poly(CL‐co‐ACL)]) was synthesized via ring opening polymerization. This polymer was then functionalized via the pendant amine to induce antimicrobial efficacy. This was done through the grafting of poly(lysine) onto the amine as well as the quaternization of the amine using alkyl halides. The chemical structures of the synthesized monomers and polymers were confirmed using nuclear magnetic resonance (¹H NMR and ¹³C NMR) spectroscopy and attenuated total reflection‐Fourier transform infrared spectroscopy. The molecular weights of the polymers were determined using gel permeation chromatography. Nanofibre scaffolds were produced from the polymers using the electrospinning technique and these were characterized though scanning electron microscopy. The antimicrobial efficacy of the fabricated materials was tested against the Gram‐positive (Staphylococcus aureus ATCC 25923) and Gram‐negative (Pseudomonas aeruginosa ATCC 27853) bacteria using the disc diffusion and shake flask methods. The polymers demonstrated excellent antimicrobial efficacy. The fibers were exceptionally biodegradable which opens a lot of applications in the biomedical space.

中文翻译：

基于ε-己内酯衍生物的抗菌和可生物降解材料

适当的伤口护理对于预防伤口和术后感染仍然至关重要，这仍然是一个严重的临床问题。在这项研究中，我们报告了抗菌和可生物降解材料的成功制造，可用于医疗领域。氨基官能化的聚己内酯（PCL [Poly（CL- co- ACL）]）是通过开环聚合反应合成的。然后通过侧胺将这种聚合物官能化以诱导抗菌功效。这是通过将聚（赖氨酸）接枝到胺上以及使用烷基卤对胺进行季铵化来完成的。合成的单体和聚合物的化学结构已通过核磁共振（¹ H NMR和¹³C NMR）光谱和衰减全反射-傅立叶变换红外光谱。使用凝胶渗透色谱法测定聚合物的分子量。使用静电纺丝技术从聚合物中生产出纳米纤维支架，并通过扫描电子显微镜对其进行了表征。使用圆盘扩散和摇瓶法测试了所制备材料对革兰氏阳性菌（金黄色葡萄球菌ATCC 25923）和革兰氏阴性菌（铜绿假单胞菌ATCC 27853）的抗微生物作用。该聚合物表现出优异的抗微生物功效。纤维具有极高的生物降解性，在生物医学领域开辟了许多应用。

更新日期：2020-11-25

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