Development of novel therapies for temporal lobe epilepsy is hindered by a lack of models suitable for drug screening. While testing the hypothesis that “inhibiting inhibitory neurons” was sufficient to induce seizures, it was discovered that a mild electrical kindling protocol of VGAT‐Cre mice led to spontaneous motor and electrographic seizures. This study characterizes these seizures and investigates the mechanism.

中文翻译：

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点燃的 VGAT-Cre 小鼠作为颞叶癫痫新动物模型的表征

缺乏适合药物筛选的模型阻碍了颞叶癫痫新疗法的开发。在测试“抑制抑制性神经元”足以诱发癫痫发作的假设时，发现 VGAT-Cre 小鼠的温和电点燃方案导致自发运动和电图癫痫发作。本研究描述了这些癫痫发作的特征并研究了其机制。