INTRODUCTION The motor weakness in sporadic hemiplegic migraine (SHM) is a poorly understood aura manifestation. Cortical spreading depression affecting motor excitability and alterations of neurovascular coupling may be integral to the development of migraine aura. METHODS We studied 10 right-handed SHM patients and 17 healthy controls with functional near-infrared spectroscopy (fNIRS) in the interictal period. Subjects performed a finger opposition task and had real time determination of oxyhemoglobin (OxyHb) and deoxyhemoglobin (deOxyHb) changes. Recordings were completed with 10 left and 10 right sided cortical channels. RESULTS Mean baseline to peak changes were significantly reduced in SHM patients as compared to controls bilaterally only for OxyHb measurements in the anteromedial channels. Mean time to peak changes were significant delayed in SHM patients compared to controls bilaterally largely for OxyHb measurements in the posterolateral channels, with the exception of 2 recording channels. CONCLUSIONS Our findings suggest presence of abnormal interictal hemodynamic responses to increased metabolic demands during motor activation in SHM. These bilateral cerebrovascular changes involve OxyHb to a much larger degree than deOxyHb. Baseline to peak changes were evident more in the anteromedial channels, whereas time to peak changes were more evident in the posterolateral channels. These findings suggest that oxygen inflow into specific brain regions may be defective in SHM as opposed to oxygen utilization. Our findings suggest that in SHM, enduring hemodynamic deficits in response to an impending motor task are evident, which can be further explored in future studies, and possibly therapeutic trials.

中文翻译：

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散发性偏瘫性偏头痛运动激活期间发作间期血流动力学异常：一项探索性研究

介绍 散发性偏瘫性偏头痛 (SHM) 的运动无力是一种知之甚少的先兆表现。影响运动兴奋性的皮质扩散抑制和神经血管耦合的改变可能是偏头痛先兆的发展不可或缺的一部分。方法我们在间歇期使用功能性近红外光谱 (fNIRS) 研究了 10 名右手 SHM 患者和 17 名健康对照者。受试者执行手指对立任务并实时测定氧合血红蛋白 (OxyHb) 和脱氧血红蛋白 (deOxyHb) 的变化。用 10 个左侧和 10 个右侧皮质通道完成录音。结果 与对照组相比，SHM 患者的平均基线峰值变化显着降低，仅在前内侧通道中进行 OxyHb 测量。与对照组相比，SHM 患者达到峰值变化的平均时间显着延迟，主要是由于后外侧通道中的 OxyHb 测量，除了 2 个记录通道。结论 我们的研究结果表明，在 SHM 运动激活期间，对增加的代谢需求存在异常的发作间期血流动力学反应。这些双侧脑血管变化涉及 OxyHb 的程度比 deOxyHb 大得多。基线到峰值的变化在前内侧通道中更明显，而峰值时间变化在后外侧通道中更明显。这些发现表明，与氧气利用相反，SHM 中特定大脑区域的氧气流入可能存在缺陷。我们的研究结果表明，在 SHM 中，对即将发生的运动任务做出反应的持久血流动力学缺陷是显而易见的，