A prominent medical application of nanotechnology is represented in drug delivery. In this work, carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) were used for producing CMC/PVA aqueous-based nanofibers loaded with flufenamic acid (FFA) as a drug containing amine groups. The CMC/PVA solutions with 90/10, 80/20, 70/30, 60/40 and 50/50 ratios were considered for electrospinning. Two integration methods were studied for loading FFA on the nanofibers during the electrospinning process. The characterization techniques of SEM, AFM, fluorescence microscopy and FT-IR spectroscopy were used to study the produced nanofibers, indicating a uniform distribution of FFA throughout the samples. The resulting nanofibers were formed in a diameter range of 176–285 nm and exhibited a 5 h degradation time in the PBS buffer solution. A standard diagram of drug loading was obtained for the samples. The drug release pattern was examined using a dialysis tube method. UV–visible spectroscopy revealed a time-dependent drug release behavior in CMC/PVA/FFA nanofibers where a sharp release occurred over the first 20 min. However, a prolonged release time of 10 h was achieved using a cross-linker (EDC).

纳米技术在医学上的杰出应用体现在药物输送中。在这项工作中，使用羧甲基纤维素（CMC）和聚乙烯醇（PVA）来生产载有氟芬那酸（FFA）作为含胺基药物的CMC / PVA水性纳米纤维。考虑将比率为90 / 10、80 / 20、70 / 30、60 / 40和50/50的CMC / PVA溶液用于静电纺丝。研究了两种整合方法，以在静电纺丝过程中将FFA负载在纳米纤维上。SEM，AFM，荧光显微镜和FT-IR光谱的表征技术用于研究所生产的纳米纤维，表明FFA在整个样品中的分布均匀。形成的纳米纤维的直径范围为176-285 nm，在PBS缓冲溶液中降解5h。获得了样品的载药量标准图。使用透析管方法检查药物释放模式。紫外可见光谱显示，在CMC / PVA / FFA纳米纤维中，药物具有随时间变化的释放行为，在最初的20分钟内释放迅速。但是，使用交联剂（EDC）可以延长10小时的释放时间。