The brain is considered to be a complex system with extremely low energy consumption and high-efficiency information transmission and processing, and this system has not been replicated by any artificial systems so far. Several studies indicate that the activity and transmission of biophotons in neural circuits may play an important role in neural information communication, while the biophotonic spectral redshift from lower to higher in animals may be related to the evolution of intelligence. The ageing processes of higher organisms are often accompanied by a decline in brain functions; however, the underlying mechanisms are unclear. Combining an ultraweak biophoton imaging system with the improved biophoton spectral analysis device, we compared and analyzed the spectra of glutamate-induced biophotonic emissions in mouse brain slices at different ages (newborn, 1, 3, 6, 12, 15, and 18 months). We found that the glutamate-induced biophotonic emissions presented a spectral blueshift from young to old mice, suggesting that the brain may transform to use relatively high-energy biophotons for neural information transmission and processing during the ageing process. Such a change may lead to a gradual decrease in the efficiency of the nervous system and provide a new biophysical mechanism for explaining the ageing-related changes in cognitive functions.

大脑被认为是一个能量消耗极低、信息传输和处理效率高的复杂系统，这个系统迄今为止还没有被任何人工系统复制过。多项研究表明，生物光子在神经回路中的活动和传递可能在神经信息交流中起重要作用，而动物的生物光子光谱红移从低到高可能与智能进化有关。高等生物的衰老过程往往伴随着大脑功能的衰退；然而，潜在的机制尚不清楚。将超弱生物光子成像系统与改进的生物光子光谱分析装置相结合，我们比较和分析了不同年龄（新生儿、1、3、6、12、15 和 18 个月）的小鼠脑切片中谷氨酸诱导的生物光子发射光谱。我们发现谷氨酸诱导的生物光子发射呈现出从年轻到年老小鼠的光谱蓝移，表明大脑可能会转变为在衰老过程中使用相对高能量的生物光子进行神经信息传输和处理。这种变化可能会导致神经系统效率逐渐降低，并为解释与衰老相关的认知功能变化提供新的生物物理机制。表明大脑可能会转变为在衰老过程中使用相对高能量的生物光子进行神经信息传输和处理。这种变化可能会导致神经系统效率逐渐降低，并为解释与衰老相关的认知功能变化提供新的生物物理机制。表明大脑可能会转变为在衰老过程中使用相对高能量的生物光子进行神经信息传输和处理。这种变化可能会导致神经系统效率逐渐降低，并为解释与衰老相关的认知功能变化提供新的生物物理机制。