Transdermal drug delivery exhibited encouraging prospects, especially through superficial drug administration routes. However, only a few limited lipophilic drug molecules could cross the skin barrier, those are with low molecular weight and rational Log P value. Microneedles (MNs) can overcome these limitations to deliver numerous drugs into the dermal layer by piercing the outermost skin layer of the body. In the case of superficial cancer treatments, topical drug administration faces severely low transfer efficiency, and systemic treatments are always associated with side effects and premature drug degradation. MN-based systems have achieved excellent technical capabilities and been tested for pre-clinical chemotherapy, photothermal therapy, photodynamic therapy, and immunotherapy. In this review, we will focus on the features, progress, and opportunities of MNs in the anticancer drug delivery system. Then, we will discuss the strategies and advantages in these works and summarize challenges, perspectives, and translational potential for future applications.

透皮给药表现出令人鼓舞的前景，尤其是通过浅表给药途径。但是，只有少数有限的亲脂性药物分子可以穿过皮肤屏障，这些分子具有低分子量和合理的Log P值。微针（MNs）可以克服这些限制，通过刺穿人体的最外层皮肤层将大量药物输送到真皮层中。在浅表癌症治疗的情况下，局部用药面临着严重的转移效率低下的问题，全身治疗总是伴随着副作用和药物过早降解。基于MN的系统已经获得了出色的技术能力，并经过了临床前化学疗法，光热疗法，光动力疗法和免疫疗法的测试。在这篇综述中，我们将重点研究抗癌药物递送系统中MN的特征，进展和机会。然后，我们将讨论这些作品中的策略和优势，并总结挑战，观点和未来应用的翻译潜力。